James Zhenggui Tang

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Breast cancer stem cells (BCSCs) are pan-resistant to different anticancer agents and responsible for cancer relapse. Disulfiram (DS), an antialcoholism drug, targets CSCs and reverses pan-chemoresistance. The anticancer application of DS is limited by its very short half-life in the bloodstream. This prompted us to develop a liposome-encapsulated DS(More)
A complete review of the records of plant virus, viroid, liberibacter and phytoplasma in New Zealand has found evidence for 220 viruses, seven viroids, two liberibacters and two phytoplasmas. Of these, 80 viruses, one viroid and two species of liberibacter have been reported as new to New Zealand since the last review in 2006. Ten viruses and two viroids,(More)
Turnip mosaic virus (TuMV) was reported in New Zealand for the first time in 1936. Until recently, TuMV had been found in nine hosts in this country. Using transmission electron microscopy, mechanical inoculation of herbaceous indicators, and molecular and serological techniques as detection and identification methods, another five new plant host records(More)
A Tropaeolum majus (nasturtium) plant with severe leaf mosaic symptoms was collected from a public park in New Zealand in September 2004. Electron microscopy of crude sap preparations revealed the presence of flexuous filamentous virus particles of different sizes. Necrotic local lesions followed by systemic leaf necrosis, chlorosis, mosaic or distortion(More)
BACKGROUND Two methoxyl poly(ethylene glycol)-poly(L-histidine)-poly(L-lactide) (mPEG-PH-PLLA) triblock copolymers with different poly(L-histidine) chain lengths were synthesized. The morphology and biocompatibility of these self-assembled nanoparticles was investigated. METHODS Doxorubicin, an antitumor drug, was trapped in the nanoparticles to explore(More)
In this study, the amphiphilic fluorinated peptide dendrons functionalized dextran (FPD-HZN-Dex) via an acid-sensitive hydrazone linkage was successfully designed and prepared for the first time. We demonstrated a spontaneous self-assembly of amphiphilic FPD-HZN-Dex into the well-defined nanoparticles with the core-shell architecture in aqueous media, which(More)
Methoxy poly(ethylene glycol)-poly(L-histidine)-poly(lactide) (mPEG(45)-PH(30)-PLA(82)) triblock copolymers self-assemble into nanoparticles by sterocomplexation. The properties of the stereocomplex nanoparticles including morphology, stability, and biocompatibility are investigated. The results reveal that the stereocomplexation between PLLA and PDLA(More)
This study aimed to design a growth factor loaded copolyester of 3-hydroxybutyrate and 3-hydroxyhexanoate (PHBHHx) nanoparticles containing 3D collagen matrix to achieve growth factor sustained release for long-term stimulation of human mesenchymal stem cells (hMSCs) proliferation/differentiation for tissue engineer application. Platelet-derived growth(More)
A novel amphiphilic biodegradable cholesterol and poly(ethylene glycol)-folate grafted poly(α,β-malic acid) (PMA-g-Chol/PEG-FA) was synthesized and characterized as self-assembled nanoparticles for targeted delivery of doxorubicin (DOX). The nanoparticles showed extremely low critical aggregation concentrations (CAC), appropriate zeta potential, narrow size(More)
An ornamental plant, Nandina domestica, has been found to be infected for the first time with Apple stem grooving virus (ASGV) in New Zealand and Alternanthera mosaic virus (AltMV) in Oklahoma, USA. ASGV may infect N. domestica latently and the symptoms observed in New Zealand are thought to be induced by the co-infecting Cucumber mosaic virus (CMV).(More)