James Winkler

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Keywords: Hurricanes Electrical network reliability Outage prediction Topological analysis Power transmission systems Power distribution systems a b s t r a c t Large tropical cyclones cause severe damage to major cities along the United States Gulf Coast annually. A diverse collection of engineering and statistical models are currently used to estimate the(More)
Current therapies for treating skeletal pain have significant limitations as available drugs (non-steroidal anti-inflammatory drugs and opiates) have significant unwanted side effects. Targeting nerve growth factor (NGF) or its cognate receptor tropomysin receptor kinase A (TrkA) has recently become an attractive target for inhibition of adult skeletal(More)
The reliability assessment of infrastructure systems providing power, natural gas, and potable water is an integral part of societal preparedness to unforeseen hazards. The topo-logical properties of interface networks connecting electric substations to water pumping stations and natural gas compressors have received little attention despite the key role(More)
BACKGROUND The presence of anti-microbial phenolic compounds, such as the model compound ferulic acid, in biomass hydrolysates pose significant challenges to the widespread use of biomass in conjunction with whole cell biocatalysis or fermentation. Currently, these inhibitory compounds must be removed through additional downstream processing or sufficiently(More)
The adaptive landscape for an industrially relevant phenotype is determined by the effects of the genetic determinants on the fitness of the microbial system. Identifying the underlying adaptive landscape for a particular phenotype of interest will greatly enhance our abilities to engineer more robust microbial strains. Visualizing evolution in real-time(More)
UNLABELLED : BACKGROUND Evolutionary dynamics of microbial organisms can now be visualized using the Visualizing Evolution in Real Time (VERT) system, in which several isogenic strains expressing different fluorescent proteins compete during adaptive evolution and are tracked using fluorescent cell sorting to construct a population history over time.(More)
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