James Wenzel

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Following high frequency stimulation of the perforant path the density of axospinous synapses from the middle third of the molecular layer of the rat dentate gyrus did not change significantly. By contrast, within this synaptic population the density of axospinous synapses containing synaptic spinules increased markedly. We interpret these results in terms(More)
The influence of long-term potentiation (induced by repeated high-frequency stimulation of the perforant pathway) on the distribution pattern of astrocyte processes in the neuropil of the hippocampal dentate area containing the potentiated synapses was investigated by quantitative electronmicroscopy. It has been found that significant changes occurred in(More)
1. In 40 three months old Wistar rats (16 trained animals, 14 active controls, 10 passive controls) the influence of learning (brightness discrimination) on the number of electronmicroscopically detectable synapses per area neuropil was studied in the stratum radiatum (CA 1) of the hippocampus. 2. 70 minutes after completion of training, the mean number of(More)
1. The influence of the cyclic N6-monobutyryladenosine-3':5'-monophosphate (mb-cAMP) on the neurogenesis was investigated by means of electron microscopic and morphometric methods at the explantate cultures of the fetal hippocampus of the rats in vitro. 2. After three days of the in vitro cultivation the neuroblasts of the treated cultures show not(More)
Previous immunocytochemical studies have shown that GABAergic nonpyramidal neurons of the rat hippocampus survive in intracerebral transplants. However, information is still lacking about the dendritic organization and the input synapses of these cells as well as their capacity to express the calcium-binding protein parvalbumin (PARV) under transplant(More)
Regarding the hippocampal formation and especially the external two thirds of it's dentate molecular layer a lot of possible morphological changes after long-term potentiation (LTP) have been described in literature. The present morphometric-stereological study of axo-spino-dendritic synapses from the inner third of the molecular layer was done under the(More)