James Waring

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Mutations in the RAD50 gene of Saccharomyces cerevisiae have been shown to reduce double strand break repair, meiotic recombination, and radiation-inducible mitotic recombination. Several different point mutations (including ochre and amber alleles) have been previously examined for effects on spontaneous mitotic recombination and did not reduce the(More)
BACKGROUND Previous studies suggest that control of Mycobacterium tuberculosis infection is compromised by the activity of regulatory T cells, including those that express CD39, an ectonucleotidase with immunosuppressive properties. Here, we examine the role of CD39 on CD4+ T cells reacting to M. tuberculosis antigens. METHODS Cryopreserved PBMC from(More)
We have constructed a synthetic open reading frame based on amino acid sequences from two conserved regions of the HIV-1 p120 env protein, and from a predicted antigenic region of the p17 gag protein. We have synthesized these genes by using the preferred codon usage for the polyhedrin gene of the baculovirus AcNPV. This synthetic gene was fused either at(More)
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