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Gene expression–based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study
TLDR
A large, training–testing, multi-site, blinded validation study to characterize the performance of several prognostic models based on gene expression for 442 lung adenocarcinomas, providing the largest available set of microarray data with extensive pathological and clinical annotation for lungAdenocARCinomas.
Current developments in salivary diagnostics.
TLDR
The findings suggest that several biomarkers are associated with distinct biological stages of these diseases and demonstrate promise as practical biomarkers in identifying and managing periodontal disease, and acute myocardial infarction.
Quantitative, multiplexed detection of bacterial pathogens: DNA and protein applications of the Luminex LabMAP system.
TLDR
It is demonstrated that the Luminex LabMAP system is a rapid, flexible platform capable of simultaneous, sensitive and specific detection of pathogens.
Interlaboratory comparability study of cancer gene expression analysis using oligonucleotide microarrays.
TLDR
The findings indicate that under properly controlled conditions it is feasible to perform complete tumor microarray analysis, from tissue processing to hybridization and scanning, at multiple independent laboratories for a single study.
Development of biosensors for cancer clinical testing.
TLDR
Application of biosensors in cancer clinical testing has several potential advantages over other clinical analysis methods including increased assay speed and flexibility, capability for multi-target analyses, automation, reduced costs of diagnostic testing and a potential to bring molecular diagnostic assays to community health care systems and to underserved populations.
Analysis of individual data from bead‐based assays (“bead arrays”)
TLDR
Individual bead measurements are used here to calculate population parameters integral to the measurement of a bead array to judge ligand binding or other activity.
Programmable nano-bio-chip sensors: analytical meets clinical.
There have been many recent advances in the nano-bio-chip analysis methodology with implications for a number of high-morbidity diseases including HIV, cancer, and heart disease. (To listen to a
Quantitative, multiplexed detection of Salmonella and other pathogens by Luminex xMAP suspension array.
TLDR
The Luminex xMAP suspension array hybridization assay is rapid, requires few sample manipulations, and provides adequate sensitivity and specificity to detect and differentiate Salmonella and nine other test organisms through direct detection of species-specific DNA sequences.
Cancer Diagnostics
TLDR
The successful application of the PACCT algorithm is described in the discussion of the recent development of the OncotypeDX™ assay and plan for a prospective trial of this assay by the NCI-supported Clinical Trials Cooperative Groups.
Multiplex microsphere immuno-detection of potato virus Y, X and PLRV.
TLDR
Results of a multiplex assay performed on viruses added to potato leaf extracts were largely similar to those of ELISA for individual viruses and results of samples infected naturally with PVX, PVY or PLRV were comparable with ELISA.
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