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Lymphocyte-specific compensation for XLF/cernunnos end-joining functions in V(D)J recombination.

• Gang Li, Frederick W Alt, +6 authors Shan Zha
• Molecular cell
• 2008

Mutations in XLF/Cernunnos (XLF) cause lymphocytopenia in humans, and various studies suggest an XLF role in classical nonhomologous end joining (C-NHEJ). We now find that XLF-deficient mouse… (More)

ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification

• Shan Zha, Craig H. Bassing, +8 authors Frederick W Alt
• The Journal of experimental medicine
• 2010

Ataxia telangiectasia mutated (ATM) deficiency predisposes humans and mice to T lineage lymphomas with recurrent chromosome 14 translocations involving the T cell receptor alpha/delta (Tcra/d) locus.… (More)

Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions.

• Shan Zha, Wenxia Jiang, +5 authors Frederick W Alt
• Proceedings of the National Academy of Sciences…
• 2011

Antigen receptor variable region exons are assembled during lymphocyte development from variable (V), diversity (D), and joining (J) gene segments. Each germ-line gene segment is flanked by… (More)

Complementary functions of ATM and H2AX in development and suppression of genomic instability.

• Shan Zha, J M Sekiguchi, James W. Brush, Craig H. Bassing, Frederick W Alt
• Proceedings of the National Academy of Sciences…
• 2008

Upon DNA damage, histone H2AX is phosphorylated by ataxia-telangiectasia mutated (ATM) and other phosphoinositide 3-kinase-related protein kinases. To elucidate further the potential overlapping and… (More)

Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient murine ES cells.

• Shan Zha, Frederick W Alt, H J Cheng, James W. Brush, Gang Li
• Proceedings of the National Academy of Sciences…
• 2007

Nonhomologous DNA end-joining (NHEJ) is a major pathway of DNA double-strand break (DSB) repair in mammalian cells, and it functions to join both specifically programmed DSBs that occur in the… (More)

murine ES cells Defective DNA repair and increased genomic instability in Cernunnos-XLF-deficient

• Shan Zha, H J Cheng, James W. Brush, Gang Li
• 2007

www.pnas.org/cgi/content/full/104/11/4518#otherarticles This article has been cited by other articles: E-mail Alerts . click here at the top right corner of the article or Receive free email alerts… (More)

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