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Reproductive experiences for women in today's affluent Western nations differ from those of women in hunting and gathering societies, who continue the ancestral human pattern. These differences parallel commonly accepted reproductive risk factors for cancers of the breast, endometrium and ovary. Nutritional practices, exercise requirements, and body(More)
West Nile virus (WNV) is a flavivirus closely related to Japanese encephalitis and St. Louis encephalitis viruses that is primarily maintained in nature by transmission cycles between mosquitoes and birds. Occasionally, WNV infects and causes disease in other vertebrates, including humans and horses. West Nile virus has re-emerged as an important pathogen(More)
BACKGROUND Monitoring of reproductive steroid hormones at the population level requires frequent measurements, hormones or metabolites that remain stable under less than ideal collection and storage conditions, a long-term supply of antibodies, and assays useful for a range of populations. We developed enzyme immunoassays for urinary pregnanediol(More)
Chemistry is in a powerful position to enhance the capabilities of DNA nanotechnology. [1, 2] DNA origami offers rationally designed nanoscale structural frameworks, [2, 3] yet chemistry can advance them by adding tailored functionality through the selective modification of nucleic acids with chemical tags. This synergistic approach has helped create new(More)
Native Americans have higher rates of alcohol use, frequency of use, and increased rates of fetal alcohol syndrome, compared with other ethnic groups (J. Hisnanick, 1992; P. A. May, 1996; J. M. Wallace et al., 2003). High prevalence rates of alcohol misuse among Native Americans must be understood in light of their unique history, which has resulted in(More)
A simulation environment for agents is presented, enabling agent-based modeling and simulation of people, systems and robots in space exploration missions. The environment allows the analysis and design of mission operation work procedures, communications and interactions between people and systems, co-located or distributed on Earth and in space. The MODAT(More)
BACKGROUND African horse sickness virus (AHSV) causes a non-contagious, infectious disease in equids, with mortality rates that can exceed 90% in susceptible horse populations. AHSV vaccines play a crucial role in the control of the disease; however, there are concerns over the use of polyvalent live attenuated vaccines particularly in areas where AHSV is(More)
We discuss problems with interpolating and extrapolating base correlation curves and examine the pricing of CDO tranches with non-standard subordination levels. We introduce an alternative risk measure, the expected loss of equity tranches. We calculate upper and lower boundaries on " base EL " , and set out the behaviours that base EL must obey. We(More)
Drug and multidrug-resistant Plasmodium falciparum malaria has existed in Thailand for several decades. Furthermore, Thailand serves as a sentinel for drug-resistant malaria within the Greater Mekong sub-region. However, the drug resistance situation is highly dynamic, changing quickly over time. Here parasite in vitro drug sensitivity is reported for(More)
Between April 2012 and June 2014, 820 laboratory-confirmed cases of the Middle East respiratory syndrome coronavirus (MERS-CoV) have been reported in the Arabian Peninsula, Europe, North Africa, Southeast Asia, the Middle East, and the United States. The observed epidemiology is different to SARS, which showed a classic epidemic curve and was over in eight(More)