James W. Owens

Learn More
Batten disease, a degenerative neurological disorder with juvenile onset, is the most common form of the neuronal ceroid lipofuscinoses. Mutations in the CLN3 gene cause Batten disease. To facilitate studies of Batten disease pathogenesis and treatment, a murine model was created by targeted disruption of the Cln3 gene. Mice homozygous for the disrupted(More)
Childhood epilepsy can be severe and even catastrophic. In these instances, cognition can be impaired-leading to long-term intellectual disabilities. One factor that could potentially cause cognitive deficits is the frequent seizures that characterize intractable epilepsy. However, it has been difficult to separate the effects seizures may have from those(More)
Experiments reported here were motivated by studies in both human epilepsy and animal models in which stunted dendritic arbors are observed. Our goal was to determine if chronic network hyperexcitability alters dendritic growth. Experiments were conducted in hippocampal slice cultures obtained from infant mice that express the fluorescent protein YFP in CA1(More)
The effects recurring seizures have on the developing brain are an important area of debate because many forms of human epilepsy arise in early life when the central nervous system is undergoing dramatic developmental changes. To examine effects on glutamatergic synaptogenesis, epileptiform activity was induced by chronic treatment with GABAa receptor(More)
The OECD conventional 28-day repeat dose toxicity test (OECD TG 407) is widely employed in the initial hazard identification and characterization for commercial chemicals. The OECD has recently undertaken an international effort to “enhance” the conventional 28-day repeat dose toxicity test (OECD TG 407) in order to ensure that chemicals acting through(More)
Differing experimental findings with respect to "low dose" responses in the mouse prostate after in utero exposure have generated considerable controversy. An analysis of such controversies requires a broad strength and weight of the evidence approach. For example, a National Toxicology Program review panel acquired the raw data from nearly 50 studies and(More)
Air Pollution and Adverse Pregnancy Outcomes in Vancouver In the November 2003 issue of EHP, Liu et al. (2003) concluded that “relatively low concentrations of gaseous air pollutants are associated with adverse effects on birth outcomes.” Although this may be true from a purely statistical sense, there appear to be limitations of this research that suggest(More)
OBJECTIVE Hepatitis C virus (HCV) infection is the leading cause of liver failure in adulthood. Although the prevalence of HCV is reportedly as high as 80% in incarcerated adult populations, little is known about the prevalence of HCV in incarcerated juvenile populations. The purpose of this study was to determine the prevalence of HCV and high-risk(More)
The classification scheme for human health indicators in life-cycle assessment (LCA) and other toxicity scores is proposed based on identifiable target organ or system toxicity. This scheme represents a compromise between a subjective single overall score and highly detailed toxic mechanisms of action. A case study was used to evaluate the proposed(More)