James W. Mizgala

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Biodegradable beta-tricalcium phosphate disks (TCP) of two configurations were inserted into 15-mm-diameter craniotomy wounds and nontreated control sites were evaluated in 60 rabbits. There were no adverse tissue reactions and no apparent difference in the clinical appearance of the 12- and 24-week implanted disks. By 36 weeks and continuing to 48 weeks,(More)
Although bone matrix derivatives have been shown to induce new bone formation, little is known about the mechanism of matrix-induced osteogenesis. We produced antisera and monoclonal antibodies reactive with bovine bone morphogenetic protein (bBMP) and applied them to tissue sections alone and in combination with histochemical and auturadiographic methods.(More)
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