James W H Blake

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We describe a rapid method for the estimation of adenosine deaminase (ADA) activity in cerebrospinal, pleural, peritoneal, and pericardial fluids. Tuberculous effusions show significantly higher levels of ADA activity compared with effusions due to other underlying lesions such as neoplasms, bacterial and viral infections and simple transudates. Similarly,(More)
To assess racial difference in cardiac responses to elevated blood pressure, we compared echocardiographic measurements of left ventricular (LV) mass and the wall thickness to chamber dimension ratio (relative wall thickness) in 380 white and 47 black patients with uncomplicated essential hypertension consecutively enrolled in echocardiographic research(More)
Myeloperoxidase (MPO) is associated with risk in acute coronary syndromes. However, the precise role it plays in ST-elevation myocardial infarction (STEMI) remains unclear. In this study we tested the hypothesis that levels of MPO in plasma after a myocardial infarction are affected by its ability to bind to the endothelium and there is local release of the(More)
b t s t b a t b o the Editor: Acute renal injury after exposure to radiographic ontrast media, contrast-induced nephropathy (CIN), accounts for substantial proportion of all cases of acute renal failure (1). The ncremental presence of predisposing factors including pre-existing hronic renal impairment, contrast load, diabetes, and advancing ge contribute(More)
PURPOSE To elucidate determinants of abnormal left ventricular functional responses to exercise in hypertensive patients. PATIENTS AND METHODS One hundred twenty-seven patients with uncomplicated essential hypertension were studied by rest and exercise radionuclide angiography and by echocardiography at rest. RESULTS The 24 patients with subnormal left(More)
Increased cardiac performance has been documented in patients with early systemic hypertension, but its prevalence and determinants in patients with uncomplicated sustained essential hypertension have not been characterized. Radionuclide cineangiography in 116 patients with uncomplicated essential hypertension showed that 12 of 116 (10%) had supranormal(More)
AIMS To investigate the safety and efficacy of everolimus-eluting stents (EES) in a real world population, including those with high-risk characteristics and complex lesions. METHODS In this report, we analyze 2-year outcomes in 500 consecutive unselected patients treated with EES between April 2007 and March 2008. All patients were followed for 2 years(More)
We have investigated the safety and efficacy of sealing the femoral arterial puncture site using purified bovine collagen in the catheter laboratory immediately after coronary stent implantation. Ten consecutive patients, mean age 64.6 years, pretreated with heparin, aspirin, and dextran underwent the insertion of a collagen plug immediately after coronary(More)