• Publications
  • Influence
NRP1 function and targeting in neurovascular development and eye disease
Neuropilin 1 (NRP1) is expressed by neurons, blood vessels, immune cells and many other cell types in the mammalian body and binds a range of structurally and functionally diverse extracellularExpand
  • 26
  • 2
  • PDF
VEGF165-induced vascular permeability requires NRP1 for ABL-mediated SRC family kinase activation
The vascular endothelial growth factor (VEGF) isoform VEGF165 stimulates vascular growth and hyperpermeability. Whereas blood vessel growth is essential to sustain organ health, chronicExpand
  • 26
  • 2
Evaluating Vascular Hyperpermeability-inducing Agents in the Skin with the Miles Assay
The primary function of the vascular endothelium in vertebrate organisms is to serve as a barrier between the blood and each tissue of the body, whereby the permeability of the endothelium to bloodExpand
  • 7
  • PDF
Use of the HPRT gene to study nuclease-induced DNA double-strand break repair
Understanding the mechanisms of chromosomal double-strand break repair (DSBR) provides insight into genome instability, oncogenesis and genome engineering, including disease gene correction. ResearchExpand
  • 4
  • PDF
VEGF188 promotes corneal reinnervation after injury
Vascular endothelial growth factor A (VEGF) induces angiogenesis and vascular hyperpermeability in ocular tissues and is therefore a key therapeutic target for eye conditions in which these processesExpand
  • 2
  • PDF
The Role of the Neuropilins in Developmental Angiogenesis
The process of angiogenesis, defined as the sprouting of new blood vessels from existing ones, is a key process in the development of the cardiovascular system and is tightly regulated by a plethoraExpand
  • 1
James Hope (1803-1882)
Tamoxifen-Activated CreERT Impairs Retinal Angiogenesis Independently of Gene Deletion
Correspondence to: Christiana Ruhrberg, PhD, UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, United Kingdom. Email c.ruhrberg@ucl.ac.uk *J.T.B. andExpand
  • 1
VEGF Isoforms and NRP1 in Vascular Hyperpermeability
The cardiovascular system serves to deliver oxygen and nutrients to the tissues of the body whilst simultaneously removing waste products. Blood vessels display a degree of basal permeability toExpand