James T. Brash

Publications10
h-index4
Citations67
Highly Influential Citations4
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NRP1 function and targeting in neurovascular development and eye disease
Neuropilin 1 (NRP1) is expressed by neurons, blood vessels, immune cells and many other cell types in the mammalian body and binds a range of structurally and functionally diverse extracellular… Expand
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VEGF165-induced vascular permeability requires NRP1 for ABL-mediated SRC family kinase activation
The vascular endothelial growth factor (VEGF) isoform VEGF165 stimulates vascular growth and hyperpermeability. Whereas blood vessel growth is essential to sustain organ health, chronic… Expand
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Evaluating Vascular Hyperpermeability-inducing Agents in the Skin with the Miles Assay
The primary function of the vascular endothelium in vertebrate organisms is to serve as a barrier between the blood and each tissue of the body, whereby the permeability of the endothelium to blood… Expand
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Use of the HPRT gene to study nuclease-induced DNA double-strand break repair
Understanding the mechanisms of chromosomal double-strand break repair (DSBR) provides insight into genome instability, oncogenesis and genome engineering, including disease gene correction. Research… Expand
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VEGF188 promotes corneal reinnervation after injury
Vascular endothelial growth factor A (VEGF) induces angiogenesis and vascular hyperpermeability in ocular tissues and is therefore a key therapeutic target for eye conditions in which these processes… Expand
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The Role of the Neuropilins in Developmental Angiogenesis
The process of angiogenesis, defined as the sprouting of new blood vessels from existing ones, is a key process in the development of the cardiovascular system and is tightly regulated by a plethora… Expand
  • 1
James Hope (1803-1882)
The New Scottish County Electors in 1832: An Occupational Analysis
Tamoxifen-Activated CreERT Impairs Retinal Angiogenesis Independently of Gene Deletion
Correspondence to: Christiana Ruhrberg, PhD, UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, United Kingdom. Email c.ruhrberg@ucl.ac.uk *J.T.B. and… Expand
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VEGF Isoforms and NRP1 in Vascular Hyperpermeability
The cardiovascular system serves to deliver oxygen and nutrients to the tissues of the body whilst simultaneously removing waste products. Blood vessels display a degree of basal permeability to… Expand