James T. Sawyer

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We previously demonstrated that a heterotypic complex of the two rat asialoglycoprotein receptor subunits was assembled during cell-free translation (Sawyer, J. T., and D. Doyle. 1990. Proc. Natl. Acad. Sci. USA. 87:4854-4858). We have characterized this system further by analyzing polypeptide interactions under both reducing and oxidizing translation(More)
For simulation practitioners, the common steps in a simulation modeling engagement are likely familiar: problem assessment, requirements specification, model building, verification, validation, and delivery of results. And for industrial engineers, it's a well-known adage that paying careful attention to <i>process</i> can help achieve better results. In(More)
SIMCAP (Simulation-based Capacity Analysis Platform) is a simulation-based software tool designed to support analysis of intermodal terminal operation, specifically with respect to track capacity and yard capacity. The application was designed with a modular, extensible software architecture with an emphasis on capturing the primary complexities that exist(More)
In the industrial engineering community, it's a well-known adage that focusing on <i>process</i> can help achieve better results. In this second of a series of papers, we'll focus on the <i>process of simulation testing</i> and outline how improving your testing process can lead to better results for your projects. We'll consider model building as a(More)
Design of effective support tools for human interaction with a complex system requires models of both the human and the system. Models of the human are necessary in order to understand and evaluate the behavioral demands imposed by the system. Models of the system are necessary in order to comprehend the complexities of the work domain. The potential(More)
Simulation modeling is a proven technology to help companies make better decisions for both strategic planning and day-today operations. A computer model is created that mimics the operation of a real-world system or process over time. The model is then used to understand, analyze, and predict the system's behavior across a wide variety of " what-if "(More)
This presentation reviews modeling transportation systems which include port operations and the extended railroad network used by port related traffic. The case study presented encompasses the port systems and rail networks of the Pacific Northwest. A new approach for unloading and loading ships at port is introduced in this presentation. Traditionally, a(More)
An intermodal rail terminal is a facility where the transfer of cargo occurs between truck and rail. The operations within these terminals involve many resources and operating rules. The ability of a terminal to respond to activity peaks that occur as a result of train arrivals and departures is critical. In order to explore how operations can be improved(More)