James T. Murphy

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Simulations were carried out to analyze a promising new antimicrobial treatment strategy for targeting antibiotic-resistant bacteria called the \beta-lactamase-dependent prodrug delivery system. In this system, the antibacterial drugs are delivered as inactive precursors that only become activated after contact with an enzyme characteristic of many species(More)
There are global increases in the use of HIV antiretroviral therapy (ART), guided by clinical benefits of early ART initiation, and the efficacy of treatment as prevention of transmission. Separately, it has been shown theoretically and empirically that HIV virulence can evolve over time. Observed virulence levels may reflect an adaptive balance between(More)
The data presented in this article are related to the research article entitled "A modelling approach to explore the critical environmental parameters influencing the growth and establishment of the invasive seaweed Undaria pinnatifida in Europe" [1]. This article describes raw simulation data output from a novel individual-based model of the invasive kelp(More)
Invasive macroalgae form a substantial component of marine invaders at a global level. However, it is poorly understood how the complex interactions between local environmental conditions and life cycle dynamics contribute to invasion success from a mechanistic viewpoint. The aim of this study was to use a model (UndariaGEN) that incorporates a detailed(More)
We introduce the explosion problem for semilinear elliptic and parabolic PDEs. The explosion problem is a question of existence of nonnegative solutions to −Lφ = λg(x, φ) and nonnegative global solutions to ∂tφ − Lφ = λg(x, t, φ). Under certain conditions there is a λ * > 0, called the explosion threshold, for which λ < λ * implies a solution exists, and λ(More)
mass transfer mechanism. This may help simplify future models. Most of our work was implemented using Python scripts; we used Crank-Nicolson finite difference schemes, second order accurate in space, first order in the time-like sense. The velocity field within the test apparatus was produced by D'Arcy et al using the commercial CFD code Fluent. LPA and(More)