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Mutations are the raw material of evolution but have been difficult to study directly. We report the largest study of new mutations to date, comprising 2,058 germline changes discovered by analyzing 85,289 Icelanders at 2,477 microsatellites. The paternal-to-maternal mutation rate ratio is 3.3, and the rate in fathers doubles from age 20 to 58, whereas(More)
Preface This user guide is intended for clinicians with some knowledge of programming and/or graduate-level researchers with knowledge of biomedical signal processing. The user is expected to have a working knowledge of SQL. Basic knowledge of a statistical (signal processing) package such as Matlab or R is useful. Knowledge of C/C++ and/or Java may also(More)
OBJECTIVE The value of different algorithms that estimate cardiac output (CO) by analysis of a peripheral arterial blood pressure (ABP) waveform has not been definitively identified. In this investigation, we developed a testing data set containing a large number of radial ABP waveform segments and contemporaneous reference CO by thermodilution(More)
Microsatellite length mutations are often modeled using the generalized stepwise mutation process, which is a type of random walk. If this model is sufficiently accurate, one can estimate the coalescence time between alleles of a locus after a mathematical transformation of the allele lengths. When large-scale microsatellite genotyping first became(More)
Cardiac output (CO) is a cardinal parameter of cardiovascular state, and a fundamental determinant of global oxygen delivery. Historically, measurement of CO has been limited to critically-ill patients, using invasive indicator-dilution methods such as thermodilution via Swan-Ganz lines, which carry risks. Over the past century, the premise that CO could be(More)
High brightness and efficient stacked white organic light-emitting diodes (WOLEDs) have been fabricated based on blue phosphorescent and red fluorescent emissive units consisting of NPB/mCP: FirPic/TPBi and NPB/Alq 3 : DCJTB/BCP, respectively. White light emission with CIE coordinates of (0.32, 0.38) was obtained. A luminance of 40,000cd/m 2 was obtained(More)
This deliverable is concerned with developing algorithms and tools for semantic annotation of legacy software artefacts, with respect to a given domain ontology. In the case of non-textual content, e.g., screen shots and design diagrams we have applied OCR software, prior to Information Extraction. The results have been made available as a web service,(More)
BACKGROUND As of October 1, 2012, hospitals in the United States with excess readmissions based on the Centers for Medicare and Medicaid Services (CMS) risk-adjusted ratio began being penalized. Given the impact of high readmission rates to hospitals nationally, it is important for individual hospitals to identify which patients may be at highest risk of(More)
This deliverable describes the results of requirement analysis and definition of transitioning scenarios to semantic technologies that have been carried out on the open-source software engineering case study 1. It provides an outline of the application to be refactored and an introduction to the underlying application-specific concepts. A structured set of(More)
—In this paper, we examined the effect of post-packaging annealing on the performance of organic light-emitting diodes containing tris-(8-hydroxyquinoline) aluminum (Alq 3) or 2,9-Dimethyl-4,7-diphenyl-1,10-phenanthroline (BCP) in direct contact with a LiF–Al bilayer cathode. The detailed electrolu-minescent (EL) characteristics were compared before and(More)