James Stevenson

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Combinatorial organic synthesis (combinatorial chemistry or CC) and ultrahigh-throughput screening (UHTS) are speeding up drug discovery by increasing capacity for making and screening large numbers of compounds. However, a key problem is to select the smaller set of "representative" compounds from a virtual library to make or screen. Our approach is to(More)
A new approach to image retrieval is presented in the domain of museum and gallery image collections. Specialist algorithms, developed to address specific retrieval tasks, are combined with more conventional content and metadata retrieval approaches, and implemented within a distributed architecture to provide cross-collection searching and navigation in a(More)
The paper describes the prototype design and development of a multimedia system for museums and galleries. Key elements in the system are the introduction of 3-D models of museum artefacts together with 3-D as well as 2-D content based retrieval and navigation facilities and the development of a semantic layer, centred on an ontology for museums, which aims(More)
A complete tool chain starting with stereo photogrammetry based digitization of artefacts, their refinement, collection and management with other multimedia data, and visualization using virtual and augmented reality is presented. Our system provides a one-stop-solution for museums to create, manage and present both content and context for virtual(More)
The paper describes work which is part of the Artiste project to develop a distributed database of Art Images from four niajor European art galleries. One aspect of the project involves the developnient of content-based retrieval and navigation facilities. A particular objective is to provide a facility for retrieving an image from the collection or(More)
SCULPTEUR is an EU/IST funded collaborative research project concerned with the application of knowledge and semantic web technologies to the problem of multimedia information management in the cultural heritage domain. An important aspect of the project is the development of a semantic layer centred on an ontological representation of the domain which(More)
The lipid bilayer membrane, which is the foundation of life on Earth, is not viable outside of biology based on liquid water. This fact has caused astronomers who seek conditions suitable for life to search for exoplanets within the "habitable zone," the narrow band in which liquid water can exist. However, can cell membranes be created and function at(More)
Parkinson's disease (PD), the most common neurodegenerative movement disorder, has traditionally been considered a "classic" basal ganglia disease, as the most obvious pathology is seen in the dopaminergic cells in the substantia nigra pars compacta. Nevertheless recent discoveries in anatomical connections linking the basal ganglia and the cerebellum have(More)
In a thromboembolic stroke model after reperfusion by recombinant tissue plasminogen activator (rt-PA), we aimed to determine whether therapeutic hypothermia (TH) and ethanol (EtOH) in combination with low concentration (60 %) of normobaric oxygen (NBO) enhanced neuroprotection, as compared to using each of these agents alone. We further aimed to elucidate(More)
  • Stefanie Galbán, Yong Hyun Jeon, Brittany M. Bowman, James Stevenson, Katrina A. Sebolt, Lisa M. Sharkey +14 others
  • 2013
In addition to their degradative role in protein turnover, proteases play a key role as positive or negative regulators of signal transduction pathways and therefore their dysregulation contributes to many disease states. Regulatory roles of proteases include their hormone-like role in triggering G protein-coupled signaling (Protease-Activated-Receptors);(More)