James Small

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Co-administration of piperonyl butoxide (PB) potentiates fenbendazole (FBZ) in small ruminants. The resultant increase in bioavailability of FBZ and its metabolite oxfendazole (OFZ) has important implications for the efficacy of these drugs against benzimidazole (BZD)-resistant strains of Teladorsagia circumcincta. This study evaluated the racemic (achiral)(More)
The effect of increasing time of hemorrhage-induced hypotension on basal splanchnic prostanoid (PG) release was examined. Male Sprague-Dawley rats were anesthetized and hemorrhaged to 30 mm Hg for 30, 60, or 120 min (SK-30, SK-60, SK-120 groups). Following shock, the superior mesenteric artery and its end organ intestine (SV + SI) was cannulated and(More)
A technique was developed for the resuscitation of hypothermic newborn lambs. This technique consisted of three major components: the administration of glucose solution by intraperitoneal injection to lambs aged six hours or more in order to reverse hypoglycaemia (10 ml/kg of a 20 per cent solution); rewarming the lambs in air at 40 degrees C; and careful(More)
More than 500 cases of watery mouth in newborn lambs were recorded in 11 flocks and a detailed examination was performed in more than 200 cases. The condition occurred predominantly in lambs aged 24 to 48 hours. The incidence in a flock varied from 1 per cent to 24 per cent and the mortality in affected lambs varied from 7 per cent to 83 per cent. A(More)
1. The effect of co-administration of either short- or long-acting formulations of DXM on hepatic function and the plasma pharmacokinetic behaviour of prochiral fenbendazole (FBZ) and its metabolites was evaluated in sheep. 2. Neither DXM treatment markedly affected any of the biochemical markers of hepatic function tested. In contrast, both formulations(More)
Basal metabolic rate and then summit metabolic rate were measured using a water immersion technique in newborn lambs at 1 h or 4 h old. The mean rates of basal and summit metabolism were 51 +/- 1.5 and 235 +/- 7.9 w per m2 respectively. Summit metabolic rate was more closely related to body surface area than to body weight. Umbilical catheters were inserted(More)
The causes of hypothermia in 89 lambs were identified on the basis of history and clinical biochemistry. Excessive heat loss accounted for 24 per cent of the cases, and depressed heat production because of either severe hypoxia during birth, immaturity or starvation accounted for 72 per cent. Exhaustion of energy reserves and hypoglycaemia were marked(More)
The feeding of colostrum to newborn lambs led to a 17 to 20 per cent increase in summit metabolic rate estimated at five hours of age. This increase would significantly enhance the survival potential of the newborn lamb in the field. Respiratory quotient during summit metabolism and changes in plasma composition suggested that the carbohydrate content of(More)
1. Suvorexant (MK-4305, Belsomra®) is a first-in-class dual orexin receptor antagonist approved in the USA and Japan for the treatment of insomnia. The current studies describe suvorexant's absorption, disposition and potential for CYP-mediated drug interactions in humans. 2. Following single oral administration of [(14)C]suvorexant to healthy human(More)