James Shields

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We evaluated a comprehensive national database that documents canine infection with, or exposure to, four vector-borne disease agents, Dirofilaria immitis, Borrelia burgdorferi, Ehrlichia canis, and Anaplasma phagocytophilum in order to assess geographic trends in rates of positive tests. While the percent positive test results varied by agent in different(More)
We evaluated the prevalence of selected vector-borne diseases in 131 dogs in an animal shelter in central Spain using point-of-care assays (SNAP 4DX and SNAP Leishmania; IDEXX Laboratories, Westbrook, ME). The SNAP 4DX detects Dirofilaria immitis (Di) antigen and antibodies against Ehrlichia canis (Ec), Borrelia burgdorferi (Bb), and Anaplasma(More)
OBJECTIVE We investigated the ability of clinical drug of abuse tests to detect synthetic cannabinoids. RESULTS A broad class GC/MS drug screening method detected JWH-018 and JWH-073 in methanolic extracts and teas steeped from herbal incense products in three of four products tested. CONCLUSIONS Synthetic cannabinoids are present in herbal incense(More)
The dramatic reduction in perinatal morbidity and mortality over the last decade has not been accompanied by any diminution in the incidence of cerebral palsy. We investigated retrospectively the relationship of certain perinatal events to the subsequent development of cerebral palsy in 75 infants. Cerebral palsy occurred in association with acute(More)
We studied the nonstress test (NST) results and other perinatal features of 44 children with cerebral palsy, who had fetal heart rate (FHR) patterns during labor suggesting preexisting injury. This was a retrospective, descriptive study. All fetuses persistently showed absent variability and small, variable decelerations, with overshoot from the onset of(More)
sible with LC-MS/MS for combined immunosuppressive therapies where a calcineurin inhibitor is used together with a mTOR inhibitor because both drugs can be quantified with a single assay. Because of its ease and rapidity, this method is ideally suited for the routine monitoring of these four major immunosuppressive drugs in clinical practice. Laboratories(More)