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This paper discusses methods for assigning codewords for the purpose of fingerprinting digital data, e.g., software, documents, music, and video. Fingerprinting consists of uniquely marking and registering each copy of the data. This marking allows a distributor to detect any unauthorized copy and trace it back to the user. This threat of detection will(More)
INTRODUCTION Many patients who suffer cardiac arrest do not respond to standard cardiopulmonary resuscitation. There is growing interest in utilizing veno-arterial extracorporeal membrane oxygenation assisted cardiopulmonary resuscitation (E-CPR) in the management of refractory cardiac arrest. We describe our preliminary experiences in establishing an E-CPR(More)
The progression from cardiac injury to symptomatic heart failure has been intensely studied over the last decade, and is largely attributable to a loss of functional cardiac myocytes through necrosis, intrinsic and extrinsic apoptosis pathways and autophagy. Therefore, the molecular regulation of these cellular programs has been rigorously investigated in(More)
Earlier we identified a survival role for NF-kappaB in ventricular myocytes, however, the underlying mechanism was undefined. In this report we provide new mechanistic evidence that the hypoxia-inducible death factor BNIP3 is transcriptionally silenced by NF-kappaB through a mechanism that involves the cooperative actions of HDAC1. Activation of the(More)
Studies have shown a reduction in plaque volume and change in plaque ultrasound characteristics after 4 infusions of reconstituted high-density lipoprotein (rHDL). Whether rHDL infusion leads to acute changes in plaque characteristics in humans is not known. Patients with claudication scheduled for percutaneous superficial femoral artery revascularization(More)
Creating high-quality multimedia presentations requires much skill, time, and effort. This is particularly true when temporal media, such as speech and animation, are involved. We describe the design and implementation of a knowledge-based system that generates customized temporal multimedia presentations. We provide an overview of the system’s(More)
Information seeking is an important but often difficult task, especially when it involves large and complex data sets. We hypothesize that a context-sensitive interaction paradigm would greatly assist users in their information seeking. Such a paradigm would allow users to both express their requests and receive requested information in context. Driven by(More)
The human ether-a-go-go-related gene (hERG) encodes a channel that conducts the rapidly activating delayed rectifier K(+) current (I(Kr)), which is important for cardiac repolarization. Mutations in hERG reduce I(Kr) and cause congenital long QT syndrome (LQTS). More frequently, common medications can reduce I(Kr) and cause LQTS as a side effect. Protein(More)
The cell cycle factor E2F-1 is known to regulate a variety of cellular processes including apoptosis. Previously we showed that disruption of Rb-E2F-1 complexes provoked apoptosis of postmitotic adult and neonatal ventricular myocytes; however, the underlying mechanism was undetermined. In this report, we show that E2F-1 provokes cell death of ventricular(More)