James S. Jones

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Some models of sexual selection depend on a female preference for 'good genes': females choose conspicuous males as these are advertising their possession of genes for fitness characters which can be inherited by their offspring. In contrast, Fisher's fundamental theorem of natural selection - which underlies much of population genetics theory - predicts(More)
Redox cycling of catecholestrogen metabolites between quinone and catechol forms is a mechanism of generating potentially mutagenic oxygen radicals in estrogen-induced carcinogenesis. Consistent with this concept, multiple forms of oxygen radical-generated DNA damage are induced by estrogen in cell-free systems, in cells in culture and in rodents prone to(More)
This paper discusses the role of participatory teaching methods in the computer science classroom. The list of these methods includes brainstorming, directed dialogues, small discussion groups, role playing, games, debates, panel discussions, and Socratic dialogues. The author has used such methods in Computers and Society classes and to a limited degree in(More)
We have examined the transcript levels of the Saccharomyces cerevisiae DNA repair gene RAD18 in UV irradiated cells, in the mitotic cell cycle, and during meiosis. Levels of RAD18 mRNA increased upon UV irradiation, but remained constant during the mitotic cell cycle. During meiosis, RAD18 mRNA levels rose about 4 fold at a stage coincident with the period(More)
Samples of 231 populations of the land snails Cepaea nemoralis and C. hortensis from Britain, France, Switzerland and Spain were analysed for genetic polymorphism in six enzyme systems. These sibling species show similar levels of variation detected by electrophoresis, and have a generally similar degree of local divergence over homologous enzyme loci. As(More)
Enzyme polymorphisms in the land snail Cepaea nemoralis in the central Pyrenees show concordant geographic patterns of strong differentiation that are not correlated with the distributions of characters of shell color and banding or with the major pattern of variation in climate and vegetation type. Three regions of relative genetic uniformity separated by(More)
The RAD18 gene of Saccharomyces cerevisiae is required for postreplication repair of UV damaged DNA. We have isolated the RAD18 gene, determined its nucleotide sequence and examined if deletion mutations of this gene show different or more pronounced phenotypic effects than the previously described point mutations. The RAD18 gene open reading frame encodes(More)