James S. Friedman

Learn More
The ongoing revolution in life sciences research is producing vast amounts of genetic and proteomic sequence data. Scientists want to pose increasingly complex queries on this data, but current methods for querying biological sequences are primitive and largely procedural. This limits the ease with which complex queries can be posed, and often results in(More)
Retinitis pigmentosa (RP) refers to a genetically heterogeneous group of progressive neurodegenerative diseases that result in dysfunction and/or death of rod and cone photoreceptors in the retina. So far, 18 genes have been identified for autosomal-dominant (ad) RP. Here, we describe an adRP locus (RP42) at chromosome 7p15 through linkage analysis in a(More)
The Kelch-like (KLHL) gene family encodes a group of proteins that generally possess a BTB/POZ domain, a BACK domain, and five to six Kelch motifs. BTB domains facilitate protein binding and dimerization. The BACK domain has no known function yet is of functional importance since mutations in this domain are associated with disease. Kelch domains form a(More)
The current and ongoing revolution in life sciences research has lead to fantastic achievements such as the sequencing of entire genomes of various organisms. Sequences are ubiquitous in life sciences applications and the sizes of many sequence databases is growing rapidly. At the same time, the complexity of the queries that scientists want to pose on(More)
  • 1