James Raftery

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BACKGROUND Cholinesterase inhibitors produce small improvements in cognitive and global assessments in Alzheimer's disease. We aimed to determine whether donepezil produces worthwhile improvements in disability, dependency, behavioural and psychological symptoms, carers' psychological wellbeing, or delay in institutionalisation. If so, which patients(More)
Historically, patients with rare diseases have been underserved by commercial drug development. In several jurisdictions, specific legislation has been enacted to encourage the development of drugs for rare diseases (orphan drugs), which would otherwise not be commercially viable. However, because of the small market, these drugs are often very expensive.(More)
OBJECTIVES To consider how the impact of the NHS Health Technology Assessment (HTA) Programme should be measured. To determine what models are available and their strengths and weaknesses. To assess the impact of the first 10 years of the NHS HTA programme from its inception in 1993 to June 2003 and to identify the factors associated with HTA research that(More)
To evaluate the relative cost-effectiveness of nicotine replacement therapy (NRT) and bupropion SR for smoking cessation, the authors reviewed published studies and developed a decision analytic model from the UK National Health Services perspective. Irrespective of the methods or assumptions involved, the results of published studies consistently indicated(More)
OBJECTIVE To compare the outcomes of home-based (using the Heart Manual) and centre-based cardiac rehabilitation programmes. DESIGN Randomised controlled trial and parallel economic evaluation. SETTING Predominantly inner-city, multi-ethnic population in the West Midlands, England. PATIENTS 525 patients referred to four hospitals for cardiac(More)
OBJECTIVE To determine the clinical effectiveness of self management compared with routine care in patients on long term oral anticoagulants. DESIGN Multicentre open randomised controlled trial. SETTING Midlands region of the UK. PARTICIPANTS 617 patients aged over 18 and receiving warfarin randomised to intervention (n = 337) and routine care (n =(More)
OBJECTIVES To compare the effectiveness and costs of a new domiciliary rehabilitation service for elderly stroke patients with geriatric day-hospital care. DESIGN Randomized controlled trial. PARTICIPANTS Stroke patients aged 55+ who required further rehabilitation after hospital discharge or after referral to geriatricians from the community. SETTING(More)
OBJECTIVES To assess the effectiveness and cost-effectiveness of epoetin alpha, epoetin beta and darbepoetin alpha (referred to collectively in this report as epo) in anaemia associated with cancer, especially that attributable to cancer treatment. DATA SOURCES Electronic databases were searched from 2000 (1996 in the case of darbepoetin alpha) to(More)