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Organised Genome Dynamics in the Escherichia coli Species Results in Highly Diverse Adaptive Paths
An important adaptive role for metabolism diversification within group B2 and Shigella strains is found, but few or no extraint intestinal virulence-specific genes are identified, which could render difficult the development of a vaccine against extraintestinal infections. Expand
Intercontinental emergence of Escherichia coli clone O25:H4-ST131 producing CTX-M-15.
A broadly disseminated, CTX-M-15-positive and virulent E. coli clonal group with highly homogeneous virulence genotypes and subgroups exhibiting highly similar PFGE profiles is described, suggesting recent emergence. Expand
Escherichia coli sequence type ST131 as the major cause of serious multidrug-resistant E. coli infections in the United States.
BACKGROUND Escherichia coli sequence type ST131 (O25:H4), associated with the CTX-M-15 extended-spectrum beta-lactamase, has emerged internationally as a multidrug-resistant pathogen but has receivedExpand
The Epidemic of Extended-Spectrum-β-Lactamase-Producing Escherichia coli ST131 Is Driven by a Single Highly Pathogenic Subclone, H30-Rx
P pulsed-field gel electrophoresis and whole-genome sequencing are applied to reconstruct the evolutionary history of the ST131 clone and suggest that the high prevalence of CTX-M-15 production among ST131 isolates is due primarily to the expansion of a single, highly virulent subclone, H30-Rx. Expand
Medical and economic impact of extraintestinal infections due to Escherichia coli: focus on an increasingly important endemic problem.
Underappreciated features include the wide variety of extraintestinal infections E. coli can cause, the high incidence and associated morbidity, mortality, and costs of these diverse clinical syndromes, and increasing antimicrobial resistance. Expand
Molecular epidemiology of extraintestinal pathogenic (uropathogenic) Escherichia coli.
O Ongoing discovery of new putative virulence factors (VFs), increasing awareness of the importance of VF expression and molecular variants of VFs, and growing appreciation of transmission as an important contributor to ExPEC infections provide abundant stimulus for future molecular epidemiological studies. Expand
Isolation and Molecular Characterization of Nalidixic Acid-Resistant Extraintestinal Pathogenic Escherichia coli from Retail Chicken Products
The similarity of the Nal-resistant and -susceptible populations suggests that they derive from the same source population, presumably the avian fecal flora, with Nal resistance emerging by spontaneous mutation as a result of fluoroquinolone exposure. Expand
Extraintestinal pathogenic Escherichia coli: "the other bad E coli".
Broader appreciation of the existence and importance of ExPEC and better understandings of their distinctive virulence mechanisms, reservoirs, and transmission pathways may lead to effective preventive interventions against the morbid and costly infections ExPec cause. Expand
Phylogenetic origin and virulence genotype in relation to resistance to fluoroquinolones and/or extended-spectrum cephalosporins and cephamycins among Escherichia coli isolates from animals and
In E. coli, antibiotic resistance predicts phylogenetic background and virulence potential in a complex, context-dependent fashion and only among human isolate did resistance predict reduced virulence. Expand
Antimicrobial-resistant and extraintestinal pathogenic Escherichia coli in retail foods.
Retail foods may be an important vehicle for community-wide dissemination of antimicrobial-resistant E. coli and ExPEC, which may represent a newly recognized group of medically significant foodborne pathogens. Expand