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We study the problem of stable scheduling for a class of wireless networks. The goal is to stabilize the queues holding information to be transmitted over a fading channel. Few assumptions are made on the arrival process statistics other than the assumption that their mean values lie within the capacity region and that they satisfy a version of the law of(More)
— We consider wireless networks with interference constraints. The network consists of a set of links and a set of users who generate packets that traverse these links. Each user is associated with a route consisting of a sequence of links. The links are subject to the usual interference constraints: (i) if link l interferes with link k, then link k also(More)
Transient interactions, which involve protein interactions that are formed and broken easily, are important in many aspects of cellular function. Here we describe structural and functional properties of transient interactions between globular domains and between globular domains, short peptides, and disordered regions. The importance of posttranslational(More)
To examine the role of small RNAs in peripheral pain pathways, we deleted the enzyme Dicer in mouse postmitotic damage-sensing neurons. We used a Nav1.8-Cre mouse to target those nociceptors important for inflammatory pain. The conditional null mice were healthy with a normal number of sensory neurons and normal acute pain thresholds. Behavioral studies(More)
We consider a manufacturing system producing several part{types on several machines. Raw parts are input to the system. Each unit of a given part{type requires a predetermined processing time at each of several machines, in a given order. A setup time is required whenever a machine switches from processing one part{type to another. For a single machine(More)
Measuring gene transcription using real-time reverse transcription polymerase chain reaction (RT-qPCR) technology is a mainstay of molecular biology. Technologies now exist to measure the abundance of many transcripts in parallel. The selection of the optimal reference gene for the normalisation of this data is a recurring problem, and several algorithms(More)
Hundreds of genes are proposed to contribute to nociception and pain perception. Historically, most studies of pain-related genes have examined them in isolation or alongside a handful of other genes. More recently the use of systems biology techniques has enabled us to study genes in the context of the biological pathways and networks in which they(More)
—This paper considers problems motivated by the dynamic allocation of limited heterogeneous resources in new product development (NPD) projects. The interchangeability of resources and simultaneous resource sharing are defining characteristics of NPD processes. A continuous flow model is introduced that incorporates these features. For problems without(More)