James R. Dornhoffer

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The highly conserved FACT (FAcilitates Chromatin Transactions) histone chaperone assists in the transcription elongation process first by facilitating the removal of histones in front of transcribing RNA polymerase II (Pol II) and then by contributing to nucleosome reassembly in the wake of Pol II passage. Whereas it is well established that FACT localizes(More)
IMPORTANCE Endoglin (CD105) and endothelial nitric oxide synthase (eNOS) assist in regulating vascular development. Variation in expression of these factors is linked to errors in vascular growth and remodeling in invasive lesions. OBJECTIVE To clarify the role of endoglin and eNOS in the growth of extracranial head and neck arteriovenous malformations(More)
BACKGROUND Administering pharmaceuticals to the scala tympani of the inner ear is a common approach to study cochlear physiology and mechanics. We present here a novel method for in vivo drug delivery in a controlled manner to sealed ears. NEW METHOD Injections of ototoxic solutions were applied from a pipette sealed into a fenestra in the cochlear apex,(More)
PURPOSE OF REVIEW The purpose of this review is to summarize current studies detailing the impact of unilateral sensorineural hearing loss in children and the most current modalities of treatment used in its management. RECENT FINDINGS Current studies corroborate historic views on the impact of unilateral sensorineural hearing loss on patient wellbeing(More)
OBJECTIVES To assess the association of a patient's ability to perform a clinically observed Valsalva maneuver with tobacco smoking and post-ossiculoplasty outcomes. STUDY DESIGN Case series with chart review. SETTING Tertiary referral, university-based otology practice. PATIENTS Adult patients (16-88 years of age) undergoing ossiculoplasty with(More)
BackgroundPropranolol's mechanism of action for controlling infantile hemangioma (IH) remains unclear. We hypothesize that this nonselective beta antagonist downregulates renin-angiotensin-aldosterone (RAA) axis components, preventing angiogenic substrate induction of IH.MethodsIH tissue and serum were collected from children with propranolol-treated or(More)
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