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The highly conserved FACT (FAcilitates Chromatin Transactions) histone chaperone assists in the transcription elongation process first by facilitating the removal of histones in front of transcribing RNA polymerase II (Pol II) and then by contributing to nucleosome reassembly in the wake of Pol II passage. Whereas it is well established that FACT localizes(More)
BACKGROUND Administering pharmaceuticals to the scala tympani of the inner ear is a common approach to study cochlear physiology and mechanics. We present here a novel method for in vivo drug delivery in a controlled manner to sealed ears. NEW METHOD Injections of ototoxic solutions were applied from a pipette sealed into a fenestra in the cochlear apex,(More)
OBJECTIVES To assess the association of a patient's ability to perform a clinically observed Valsalva maneuver with tobacco smoking and post-ossiculoplasty outcomes. STUDY DESIGN Case series with chart review. SETTING Tertiary referral, university-based otology practice. PATIENTS Adult patients (16-88 years of age) undergoing ossiculoplasty with(More)
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