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Brainstem and forebrain projections to major subdivisions of the rat inferior colliculus were studied by using retrograde and anterograde transport of horseradish peroxidase. Retrograde label from injection into the external cortex of the inferior colliculus appears bilaterally in cells of the inferior colliculus, as well as in other brainstem auditory(More)
The projections of the rat temporal cortex to the amygdala and cerebral cortex were studied using the sensitive anterograde tracer, Phaseolus vulgaris leucoagglutinin. These studies revealed that the core of temporal area 1 had no projections to the amygdala but did send efferents to several cortical fields that projected to the amygdala, including temporal(More)
Audiogenic seizure (AGS) models of developmental or genetic origin manifest characteristic indices of generalized seizures such as clonus or tonus in rodents. Studies of seizure-resistant strains in which AGS is induced by intense sound exposure during postnatal development provide models in which other neural abnormalities are not introduced along with AGS(More)
The cytoarchitecture, myeloarchitecture, and neocortical connectivity of the rat medial geniculate body (MGB) were comprehensively studied in adult and immature rats to define major anatomical divisions and nuclei. The MGB is a highly intricate structure composed of the ventral (MGv), dorsal (MGd), and medial (MGm) divisions and component nuclei, each(More)
Binaural interactions were recorded in auditory cortical (AI) neurons of anesthetized adult cats that had unilateral atresias created shortly after birth by surgically ligating and cutting one external ear canal. At the time of the recording experiment, the atresia and associated debris were removed and tones were delivered to both tympanic membranes via a(More)
We developed a novel and game like dual 2-back computerized task, Gatekeeper, which we deployed online with 245 male and female participants ranging in age from 13 to 83 years. Gatekeeper requires participants to remember only 4 items, so does not target memory capacity, but rather measures multitasking ability and interference control in working memory.(More)
The effects of monaural deprivation by ligation of the external auditory meatus on spherical cells in the anteroventral cochlear nucleus of the rat were examined. Sound deprivation from postnatal days 10, 16, 24, and 36 resulted in a reduction in spherical cell size, with the most dramatic reduction produced by deprivation at 10 and 16 days after birth. The(More)
Audiogenic seizure susceptibility in the normally seizure-resistant Long-Evans rat may result from altered processing in the auditory pathway. Representative waveform latencies of the auditory brainstem responses (ABR) were recorded to examine generator alterations at different levels of the auditory neuraxis. Male Long-Evans rats primed for audiogenic(More)
The course of development of the auditory brainstem response (ABR) in rat was examined. Pure tone pip stimuli of 3, 8 and 40 kHz at intensities up to 106 dB sound pressure level peak equivalent were presented to anesthetized rats on postnatal days (PND) 9, 10, 12, 14, 16, 20, 24, 36, 70 and 96. The peak-to-peak amplitude and the order of appearance of each(More)