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1Department of Social Medicine, University of Bristol, Bristol BS8 2PR 2MRC Biostatistics Unit, Institute of Public Health, Cambridge CB2 0SR 3Clinical Epidemiology and Biostatistics Unit, Murdoch Children’s Research Institute, and University of Melbourne, Parkville, Victoria 3052, Australia 4Cancer and Statistical Methodology Groups, MRC Clinical Trials(More)
OBJECTIVE To resolve uncertainty as to the risk of Sudden Infant Death Syndrome (SIDS) associated with sleeping in bed with your baby if neither parent smokes and the baby is breastfed. DESIGN Bed sharing was defined as sleeping with a baby in the parents' bed; room sharing as baby sleeping in the parents' room. Frequency of bed sharing during last sleep(More)
BACKGROUND Citation counts are often regarded as a measure of the utilization and contribution of published articles. The objective of this study is to assess whether statistical reporting and statistical errors in the analysis of the primary outcome are associated with the number of citations received. METHODS We evaluated all original research articles(More)
Statistical heterogeneity and small-study effects are 2 major issues affecting the validity of meta-analysis. In this article, we introduce the concept of a limit meta-analysis, which leads to shrunken, empirical Bayes estimates of study effects after allowing for small-study effects. This in turn leads to 3 model-based adjusted pooled treatment-effect(More)
BACKGROUND A case report is a narrative that describes, for medical, scientific, or educational purposes, a medical problem experienced by one or more patients. Case reports written without guidance from reporting standards are insufficiently rigorous to guide clinical practice or to inform clinical study design. PRIMARY OBJECTIVE Develop, disseminate,(More)
Missing covariate data commonly occur in epidemiological and clinical research, and are often dealt with using multiple imputation. Imputation of partially observed covariates is complicated if the substantive model is non-linear (e.g. Cox proportional hazards model), or contains non-linear (e.g. squared) or interaction terms, and standard software(More)
There is ongoing concern about the relationship between class size and achievement for children in their first years of schooling. The Institute of Education's class size project was set up to address this issue and began recruiting in the autumn of 1996. However, because of the non-normality of achievement measures, especially in mathematics, the results(More)
Statistical methods have been developed for cost-effectiveness analyses of cluster randomised trials (CRTs) where baseline covariates are balanced. However, CRTs may show systematic differences in individual and cluster-level covariates between the treatment groups. This paper presents three methods to adjust for imbalances in observed covariates: seemingly(More)