James R. Bonelli

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OBJECTIVE To determine the effect of repeated annual influenza immunization on the host's serum antibody. DESIGN Ten year observational study with cohort design. SETTING Cystic Fibrosis Center at St. Vincent's Hospital and Medical Center, New York City, NY. PATIENTS Thirty-eight children and young adults with cystic fibrosis (CF). MEASUREMENTS Serum(More)
Influenza viruses related to the markedly antigenically divergent strains B/Yamagata/16/88 and B/Victoria/2/87 are circulating in human populations. Adults develop cross-reacting antibodies against recent and earlier influenza B virus strains after vaccination with B/Yamagata/16/88, probably because of previous influenza B virus infections or immunizations.(More)
  • J Bonelli
  • 1982
In order to investigate the effects of beta-blockade on haemodynamic response to stress, 2 groups of volunteers received either propranolol or mepindolol sulphate under basal conditions and under the stress of mental arithmetic. In control conditions, increases occurred in heart rate (HR), cardiac output (CO) and systolic and diastolic blood pressure in(More)
The time to the appearance of a peak serum antibody response to influenza virus vaccine is not clearly defined. We compared the most commonly used time intervals described in the literature--4 and 6 weeks after vaccination. We studied 118 elderly patients from three different geographic sites. The 1992 to 1993 trivalent inactivated influenza virus vaccine(More)
—Previous observations about the stable nature of coral-rich assemblages from the Middle Devonian Hamilton Group have led some researchers to invoke the primacy of ecological controls in maintaining biofacies structure through time. However, few analyses have examined the degree to which recurring biofacies vary quantitatively, and none have assessed(More)
The effect of calculation stress on hemodynamic parameters and plasma adrenalin and noradrenalin was studied in two groups of 6 male subjects, before and during beta-Blockade. One group received propranolol 15 mg i.v. and the other received mepindolol sulphate 0,5 mg i.v. There was an increase in heart rate, cardiac output and blood pressure during mental(More)
The purpose of this study was to determine whether acetaminophen impairs the immune response to influenza vaccine. Influenza vaccine is an under-utilized preventive measure, partly because of the unfounded perception that fever and myalgias frequently follow vaccination. While acetaminophen may decrease these infrequent side effects, it may also alter the(More)
  • J Bonelli
  • 1978
The hemodynamic effect of a beta-receptor blockade with mepindolol--a noncardioselective beta-receptor blocker--was studied in 6 male test subjects age 25 to 30 years with an increasing dose of isoproterenol. The cardiac output per min, the heart rate and the stroke volume, the wet blood pressure and the contractility parameters dp/dt max in the right and(More)
The aim of this study was to investigate the haemodynamics of the beta 1-selective beta-blocker bisoprolol at plasma concentrations that would be expected to block completely the cardiac beta-receptors. Seven patients with stable exercise-dependent angina pectoris received 40 mg bisoprolol, and six patients received 10 mg bisoprolol orally as a single dose.(More)
The hemodynamic effects of diltiazem were investigated in six volunteers at rest, supine and erect, under psychologic stress and orthostatic conditions. Plasma concentrations were also estimated. Under all conditions diltiazem showed a vasodilating property that was more pronounced on the arterial resistance vessels than on the pulmonary vessels. The first(More)