Learn More
Dividing cells need to coordinate the separation of chromosomes with the formation of a cleavage plane. There is evidence that microtubule bundles in the interzone region of the anaphase spindle somehow control both the location and the assembly of the cleavage furrow [1-3]. A microtubule motor that concentrates in the interzone, MKLP1, has previously been(More)
Regulation of microtubule (MT) dynamics is essential for proper spindle assembly and organization. Kinesin-8 family members are plus-end-directed motors that modulate plus-end MT dynamics by acting as MT depolymerases or as MT plus-end capping proteins. In this paper, we show that the human kinesin-8 Kif18B functions during mitosis to control astral MT(More)
Holocentric chromosomes assemble kinetochores along their length instead of at a focused spot. The elongated expanse of an individual holocentric kinetochore and its potential flexibility heighten the risk of stable attachment to microtubules from both poles of the mitotic spindle (merotelic attachment), and hence aberrant segregation of chromosomes. Little(More)
Bipolar kinesin-5 motors, essential in diverse organisms, can generate positive sliding forces between overlapped interpolar microtubules to push mitotic spindle poles apart. BMK-1, the sole Caenorhabditis elegans kinesin-5, is not essential. We have determined, by tracking pole movements in bmk-1 mutant C. elegans embryos, that BMK-1 actually resists pole(More)
3 Abstract—Running MapReduce programs in the cloud introduces this unique problem: how to optimize resource provisioning to minimize the monetary cost or job finish time for a specific job? We study the whole process of MapReduce processing and build up a cost function that explicitly models the relationship among the time cost, the amount of input data,(More)
The Drosophila protein HP1 is a 206 amino acid heterochromatin-associated nonhistone chromosomal protein. Based on the characterization of HP1 to date, there are three properties intrinsic to HP1: nuclear localization, heterochromatin binding, and gene silencing. In this work, we have concentrated on the identification of domains responsible for the nuclear(More)
During cell division, chromosomes attach to spindle microtubules at sites called kinetochores, and force generated at the kinetochore-microtubule interface is the main driver of chromosome movement. Surprisingly, kinetochores are not required for chromosome segregation on acentrosomal spindles in Caenorhabditis elegans oocytes, but the mechanism driving(More)
Large graph datasets have become invaluable assets for studying problems in business applications and scientific research. These datasets, collected and owned by data owners, may also contain privacy-sensitive information. When using public clouds for elastic processing, data owners have to protect both data ownership and privacy from curious cloud(More)
Running MapReduce programs in the cloud introduces the important problem: how to optimize resource provisioning to minimize the financial charge or job finish time for a specific job? An important step towards this ultimate goal is modeling the cost of MapReduce program. In this chapter, we study the whole process of MapReduce processing and build 1