James Porter

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nfectious diseases have recently caused substantial community and ecosystem-wide impacts in marine communities. A long-spined sea urchin disease virtually eradicated urchins from the Caribbean and facilitated a coral to algal shift on many reefs (Hughes et al. 1994). Coral diseases , such as white band (Figure 1), white plague, white pox, and aspergillosis(More)
Smart Manufacturing is the dramatically intensified and pervasive application of networked information-based technologies throughout the manufacturing and supply chain enterprise. It responds and leads to a dramatic and fundamental business transformation to demand-dynamic economics keyed on customers, partners and the public; enterprise performance;(More)
Activation of bitter taste receptors (T2Rs) in human airway smooth muscle cells leads to muscle relaxation and bronchodilation. This finding led to our hypothesis that T2Rs are expressed in human pulmonary artery smooth muscle cells and might be involved in regulating the vascular tone. RT-PCR was performed to reveal the expression of T2Rs in human(More)
  • D. Malfacini, C. Ambrosio, M. C. Gro’, M. Sbraccia, C. Trapella, R. Guerrini +5 others
  • 2015
Nociceptin/orphanin FQ (N/OFQ) controls several biological functions by selectively activating an opioid like receptor named N/OFQ peptide receptor (NOP). Biased agonism is emerging as an important and therapeutically relevant pharmacological concept in the field of G protein coupled receptors including opioids. To evaluate the relevance of this phenomenon(More)
A new series of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine (PTP) derivatives has been developed in order to explore their affinity and selectivity profile at the four adenosine receptor subtypes. In particular, the PTP scaffold was conjugated at the C2 position with the 1-(3-trifluoromethyl-benzyl)-1H-pyrazole, a group believed to confer potency and(More)
  • Sebastian Weiterer, Thomas Kohlen, Florian Veit, Lydia Sachs, Florian Uhle, Christoph Lichtenstern +3 others
  • 2015
BACKGROUND Ciliary beating by respiratory epithelial cells continuously purges pathogens from the lower airways. Here we investigated the effect of the fungal cell wall polysaccharides Galactomannan (GM) and Zymosan (Zym) on the adrenergic activated particle transport velocity (PTV) of tracheal epithelium. METHODS Experiments were performed using tracheae(More)
  • Blanca Camoretti-Mercado, Susan H. Pauer, Hwan Mee Yong, Dan’elle C. Smith, Deepak A. Deshpande, Steven S. An +2 others
  • 2015
Asthma is characterized by airway inflammation and airflow obstruction from human airway smooth muscle (HASM) constriction due to increased local bronchoconstrictive substances. We have recently found bitter taste receptors (TAS2Rs) on HASM, which increase [Ca2+]i and relax the muscle. We report here that some, but not all, TAS2R agonists decrease [Ca2+]i(More)
Structural mechanisms of modulation of γ-aminobutyric acid (GABA) type A receptors by neurosteroids and hormones remain unclear. The thyroid hormone L-3,5,3'-triiodothyronine (T3) inhibits GABA A receptors at micromolar concentrations and has common features with neurosteroids such as allopregnanolone (ALLOP). Here we use functional experiments on α 2 β 1 γ(More)
In 2006, a small group of UK academic scientists made headlines when they proposed the creation of interspecies embryos – mixing human and animal genetic material. A public campaign was fought to mobilize support for the research. Drawing on interviews with the key scientists involved, this paper argues that engaging the public through communicating their(More)
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