James Phelan

Learn More
Rat monoclonal antibodies were used to deplete selectively Lyt 2 (cytotoxic) and L3T4 (helper) T cell populations in vivo. These antibodies produced greater than 95% depletion of the respective T cell subset as determined by fluorescent antibody and cytofluorographic analyses. Antibody-treated mice were infected in the ear pinna with herpes simplex virus(More)
This paper describes the design and validation of a performance and power simulator that is part of the Mambo simulation environment for PowerPC ᭨ systems. One of the most notable features of the simulator, designated as Tempo, is the incorporation of an event-driven power model. Tempo satisfies an important need for fast and accurate performance and power(More)
The Hetch Hetchy System provides San Francisco with much of its water supply. O'Shaughnessy Dam is one component of this system, providing approximately 25% of water storage for the Hetch Hetchy System and none of its conveyance. Removing O'Shaughnessy Dam has gained interest for restoring Hetch Hetchy Valley. Removal would entail reoperating other existing(More)
Athymic nude (nu/nu) mice were inoculated in the ear pinna with 10(4) p.f.u. herpes simplex virus type 1 (strain SC 16). Initially, the virus was observed to replicate in the pinna, spreading via a neurological route to the dorsal root ganglia, spinal cord, brain and adrenal glands. Following the transfer of lymphoid cells from day 7 herpesvirus-infected(More)
Neoadjuvant chemoradiation therapy (CRT) is increasingly the standard of care for locally advanced oesophageal cancer. A complete pathological response to CRT is associated with a favourable outcome. Radiation therapy is important for local tumour control, however, radioresistance remains a substantial clinical problem. We hypothesise that alterations in(More)
This article is based on a study of the effects of a " maize extension package " on farmers' indigenous knowledge (IK) in the Jima area of Southwestern Ethiopia. Both qualitative and quantitative approaches were employed to collect information from farmers, extension workers, and researchers. Initially, semi-structured interviews and discussions were used(More)
A Ribes-infecting strain of the potexvirus Actinidia virus X (AVX-RV3124) was isolated from black currant plants (Ribes nigrum cv. Baldwin, accession 3124-03D1) showing symptoms of leaf chlorosis and deformity. This is the first description of the complete genome sequence of an isolate of this virus and the first detection of a potexvirus in Ribes. The(More)
OBJECTIVES This study examines the relationship between synovial hypoxia and cellular bioenergetics with synovial inflammation. METHODS Primary rheumatoid arthritis synovial fibroblasts (RASF) were cultured with hypoxia, dimethyloxalylglycine (DMOG) or metabolic intermediates. Mitochondrial respiration, mitochondrial DNA mutations, cell invasion,(More)