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We did expressional profiling on 24 paired samples of normal esophageal epithelium, Barrett's metaplasia, and esophageal adenocarcinomas. Matching tissue samples representing the three different histologic types were obtained from each patient undergoing esophagectomy for adenocarcinoma. Our analysis compared the molecular changes accompanying the(More)
HIV is a chronic illness that requires strict adherence to medication regimens. This study attempts to examine the patterns of highly active antiretroviral therapy adherence relative to religious beliefs in a population of perinatally HIV-infected adolescents. Eligible subjects included perinatally HIV-infected youth aged 14-22 years who knew their HIV(More)
A small interfering RNA (siRNA) nanovector with dual targeting specificity and dual therapeutic effect is developed for targeted cancer imaging and therapy. The nanovector is composed of an iron oxide magnetic nanoparticle core coated with three different functional molecules: polyethyleneimine (PEI), siRNA, and chlorotoxin (CTX). The primary amine group of(More)
Abdominoscrotal hydrocele is a rare condition where a large hydrocele is connected to a preperitoneal space through the inguinal canal. We present a case of a young male with an abdominoscrotal hydrocele who showed gross absence of an epididymis upon hydrocele removal. Upon pathological examination, epididymal tissue was found to be incorporated into the(More)
BACKGROUND Lp(a), implicated in both atherogenesis and thrombosis pathways, varies significantly by demographic and metabolic factors, providing challenges for its use in Coronary Heart Disease (CHD) risk. The purpose of this study was to investigate whether type-2 diabetic subjects, relative to non-diabetics, might benefit more from Lp(a) measurement in(More)
Breast cancer remains one of the most prevalent and lethal malignancies in women. The inability to diagnose small volume metastases early has limited effective treatment of stage 4 breast cancer. Here we report the rational development and use of a multifunctional superparamagnetic iron oxide nanoparticle (SPION) for targeting metastatic breast cancer in a(More)
Ribonucleic acid interference (RNAi) is a powerful molecular tool that has potential to revolutionize the treatment of cancer. One major challenge of applying this technology for clinical application is the lack of site-specific carriers that can effectively deliver short interfering RNA (siRNA) to cancer cells. Here we report the development and assessment(More)
OBJECTIVE To identify the prognostic variables that predict disease-specific survival and second local recurrence-free survival in patients with recurrent retroperitoneal liposarcoma so as to guide clinical management. SUMMARY BACKGROUND DATA Local recurrence after complete resection of primary retroperitoneal liposarcoma is a common clinical problem that(More)
BACKGROUND The incidence of hepatocellular carcinoma (HCC) is rising and radiofrequency ablation (RFA) appears to be increasingly used. The nationwide use and impact of RFA have not been well characterized. STUDY DESIGN We performed an historical cohort study of US patients 18 years old and older, with a diagnosis of HCC (n = 22,103) using the national(More)