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In this paper, we propose a new frequency domain approach to blind source separation (BSS) of audio signals mixed in a reverberant environment. We propose a joint diagonalization procedure on the cross power spectral density matrices of the signals at the output of the mixing system to identify the mixing system at each frequency bin up to a scale and(More)
This paper proposes a novel wideband structure for array signal processing. A new interpolation model is formed where the observations are linear functions of the source amplitudes but nonlinear in the direction of arrival (DOA) parameters. The interpolation model also applies to the narrowband case. The proposed method lends itself well to a Bayesian(More)
In this paper, we show that an NPR M-channel filter bank with a diagonal system inserted between the analysis and synthesis filter banks may be used to decompose an FIR system of order L into M complex subband components each of order L K , where K is the downsampling rate. This decomposition is at the expense of using complex arithmetic for the subband(More)
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry was used to determine the state of N-terminal acetylation of 68 ribosomal proteins from a normal strain of Saccharomyces cerevisiae and from the ard1-Delta, nat3-Delta, and mak3-Delta mutants (), each lacking a catalytic subunit of three different N-terminal acetyltransferases. A(More)
Ribosomes from the K-12 strain of Escherichia coli were analyzed with good sensitivity and high mass accuracy using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Fifty-five of the 56 subunit proteins were observable. Mass spectral peak locations were consistent with previously reported post-translational modifications(More)
An ion mobility/mass spectrometry technique has been developed to record mass-resolved ion mobility distributions for multiple ions simultaneously. The approach involves a new instrument that couples an electrospray ion source to an injected-ion drift tube/time-of-flight mass spectrometer. Individual components in a mixture of ions are separated by mobility(More)
In vitro DNA-binding assays demonstrate that the heat shock transcription factor (HSF) from the yeast Saccharomyces cerevisiae can adopt an altered conformation when stressed. This conformation, reflected in a change in electrophoretic mobility, requires that two HSF trimers be bound to DNA. Single trimers do not show this change, which appears to represent(More)
Improved procedures for guanidination of lysine-containing peptides, a derivatization that results in increased MALDI mass spectral signal intensities are presented. The complete conversion of lysines to homoarginines can be accomplished in as little as 5 min. The method is demonstrated on a model peptide and on tryptic digests of three proteins. To(More)
Two-dimensional LC combined with whole protein and peptide mass spectrometry is used to characterize proteins secreted by methicillin-resistant Staphylococcus aureus COL. Protein identifications were accomplished via off-line protein fractionation followed by digestion and subsequent peptide analysis by reverse phase LC-ESI-LTQ-FT-MS/MS. Peptide MS/MS(More)