James P. Reilly

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In this paper, we propose a new frequency domain approach to blind source separation (BSS) of audio signals mixed in a reverberant environment. We propose a joint diagonalization procedure on the cross power spectral density matrices of the signals at the output of the mixing system to identify the mixing system at each frequency bin up to a scale and(More)
In this paper, we show that an NPR M -channel filter bank with a diagonal system inserted between the analysis and synthesis filter banks may be used to decompose an FIR system of order L into M complex subband components each of order L K , where K is the downsampling rate. This decomposition is at the expense of using complex arithmetic for the subband(More)
A new method for detecting the number of signals incident upon an array of sensors is described. This new method is based on finding upper thresholds for the observed eigenvalues of the correlation matrix of the array output. The asymptotic normality of the multifold eigenvalue estimate is used to derive a prediction formula for the thresholds. Due to the(More)
This paper presents a novel Bayesian solution to the difficult problem of joint detection and estimation of sources impinging on a single array of sensors in spatially coloured noise with arbitrary covariance structure. Robustness to the noise covariance structure is achieved by integrating out the unknown covariance matrix in an appropriate posterior(More)
This paper proposes a novel wideband structure for array signal processing. A new interpolation model is formed where the observations are linear functions of the source amplitudes but nonlinear in the direction of arrival (DOA) parameters. The interpolation model also applies to the narrowband case. The proposed method lends itself well to a Bayesian(More)
Ribosomes from the K-12 strain of Escherichia coli were analyzed with good sensitivity and high mass accuracy using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Fifty-five of the 56 subunit proteins were observable. Mass spectral peak locations were consistent with previously reported post-translational modifications(More)
We propose here a new concept of peptide detectability which could be an important factor in explaining the relationship between a protein's quantity and the peptides identified from it in a high-throughput proteomics experiment. We define peptide detectability as the probability of observing a peptide in a standard sample analyzed by a standard proteomics(More)
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry was used to determine the state of N-terminal acetylation of 68 ribosomal proteins from a normal strain of Saccharomyces cerevisiae and from the ard1-Delta, nat3-Delta, and mak3-Delta mutants (), each lacking a catalytic subunit of three different N-terminal acetyltransferases. A(More)
In vitro DNA-binding assays demonstrate that the heat shock transcription factor (HSF) from the yeast Saccharomyces cerevisiae can adopt an altered conformation when stressed. This conformation, reflected in a change in electrophoretic mobility, requires that two HSF trimers be bound to DNA. Single trimers do not show this change, which appears to represent(More)