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Human and animal studies have implicated brain-derived neurotrophic factor (BDNF) in the etiology of psychiatric disorders. It is expressed in limbic regions of the brain associated with the regulation of emotionality during fetal development and in the adult animal. To further our understanding of the role of BDNF in the modulation of mood and to(More)
The identification of genetic and epigenetic alterations from primary tumor cells has become a common method to identify genes critical to the development and progression of cancer. We seek to identify those genetic and epigenetic aberrations that have the most impact on gene function within the tumor. First, we perform a bioinformatic analysis of copy(More)
Defects in mitochondrial gene expression are associated with aging and disease. Mterf proteins have been implicated in modulating transcription, replication and protein synthesis. We have solved the structure of a member of this family, the human mitochondrial transcriptional terminator MTERF1, bound to dsDNA containing the termination sequence. The(More)
Eosinophils are a major component of the inflammatory response in persistent airway inflammation in asthma. The factors that determine the retention of eosinophils in the airway remain poorly understood. Elevated levels of fibronectin have been observed in the airway of patients with asthma, and the levels correlate with eosinophil numbers. To determine if(More)
Previous research has suggested that logical competence may not always be reflected in task performances but is influenced by various moderator variables that affect the actual application of competence. The present research examines the development of conditional reasoning from the perspective of a competence-The effects of task interpretation and(More)
This article describes an analysis of the productivity of psychology faculty during their first 7 postdoctoral years. The primary goal was to provide objective data regarding the typical rates of productivity for untenured cognitive, developmental, and social psychologists who hold appointments at highly ranked institutions. Although the median rate of(More)
In this study, we hope to accomplish three aims as follows: (1) provide greater clarity regarding the nature and scope of the field of educational neuroscience, (2) propose a framework for understanding when and how neuroscientific research could be informative for educational practice, and (3) describe some examples of neuroscientific findings from the(More)
Classic and contemporary researchers have studied the child's abilities to discriminate quantitative values, understand probability, and appreciate risk and uncertainty. The current studies were designed to extend and methodologically integrate recent insights that have been made across these sub-areas. A computerized decision-making task, which allows(More)