James Nuttall

Lorenzo Frigerio2
Carla Marusic1
Alessandro Vitale1
2Lorenzo Frigerio
1Carla Marusic
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BACKGROUND Plants may represent excellent alternatives to classical heterologous protein expression systems, especially for the production of biopharmaceuticals and vaccine components. Modern vaccines are becoming increasingly complex, with the incorporation of multiple antigens. Approaches towards developing an HIV vaccine appear to confirm this, with a(More)
We have assessed the ability of the plant secretory pathway to handle the expression of complex heterologous proteins by investigating the fate of a hybrid immunoglobulin A/G in tobacco cells. Although plant cells can express large amounts of the antibody, a relevant proportion is normally lost to vacuolar sorting and degradation. Here we show that the(More)
BACKGROUND Staphylococcus aureus is an important pathogen in paediatric patients with bloodstream infections. The epidemiology of S. aureus bacteraemia, however, has not been well documented in children in South Africa. METHODS A retrospective study was conducted at a children's hospital in Cape Town, South Africa, to investigate the epidemiology of S.(More)
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