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Single-cell activity was recorded in the dorsal subnucleus of the lateral amygdala (LAd) of freely behaving rats during Pavlovian fear conditioning, to determine the relationship between neuronal activity and behavioral learning. Neuronal responses elicited by the conditioned stimulus typically increased before behavioral fear was evident, supporting the(More)
The GABAa agonist, muscimol (0.5 microgram in 0.5 microliter saline), or vehicle was infused into the lateral and basal amygdala nuclei prior to fear conditioning or testing in rats. Rats given muscimol before conditioning and saline before testing showed much less freezing to the conditioned stimulus (CS) and the context than did controls given saline(More)
Kinetic analyses of 17-hydroxylase and 17,20-desmolase activities have been performed on human adrenal microsomes from 12 individuals, aged 1-60 yr. The median Michaelis constant of 17-hydroxylase for the substrate pregnenolone was 0.09 microM, and that of 17,20-desmolase for the substrate 17-hydroxypregnenolone was 0.12 microM. The median maximum velocity(More)
BACKGROUND In patients suffering from chronic pancreatitis the risk for the development of pancreatic cancer ranges from 4 to 6 per cent. Various mutations are associated with pancreatic cancer, especially of p53 and K-ras. The incidence of these mutations in resected chronic pancreatitic tissue was investigated. METHODS In the present study DNA from 80(More)
  • J W Muller
  • 1985
The diagnosis of a palpable cyst is made by means of mammography and ultrasound. The accuracy of ultrasound in the diagnosis of cysts is very high. Patients with palpable painful cysts and cysts with a diameter of more than 2 cm should be subjected to cyst aspiration followed by pneumocystography. This procedure provides optimal diagnosis and treatment.
Radial keratotomy is a surgical procedure to correct myopia that involves placing corneal incisions of precise partial thickness to induce flattening. It has yielded positive but sometimes unpredictable results. Many surgical variables influence the final result. Among them, incision depth is probably the most difficult to control and evaluate. In this(More)
OBJECTIVE To determine the value of ultrasonographic examination in the assessment of palpable breast tumours, with special reference to the distinction between benign and malignant tumours. DESIGN Prospective ultrasonographic study; the results of the ultrasonographic examination were compared retrospectively with those of mammographic examination. (More)