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- James M. Krueger, David M. Rector, Sandip Roy, Hans P. A. Van Dongen, Gregory L. Belenky, Jaak Panksepp
- Nature Reviews Neuroscience
- 2008
Sleep is vital to cognitive performance, productivity, health and well-being. Earlier theories of sleep presumed that it occurred at the level of the whole organism and that it was governed by… (More)
- Jeannine A. Majde, James M. Krueger
- The Journal of allergy and clinical immunology
- 2005
Sleep is a fundamental physiologic process with unknown functions. It is divided into 2 distinct states: non-rapid-eye-movement sleep and rapid-eye-movement sleep. After acute infection with… (More)
- Mark R. Opp, Ferenc Obál, James M. Krueger
- The American journal of physiology
- 1991
Rats received various doses of interleukin 1 (IL-1) (range, 0.5-25.0 ng) or pyrogen-free saline intracerebroventricularly during the rest (light) and the active (dark) cycles of the day, and… (More)
- Jidong Fang, Yvette L. Wang, James M. Krueger
- The Journal of neuroscience : the official…
- 1997
Tumor necrosis factor (TNF) is a well characterized sleep-regulatory substance. To study receptor mechanisms for the sleep-promoting effects of TNF, sleep patterns were determined in control and TNF… (More)
- Ferenc Obál, James M. Krueger
- Frontiers in bioscience : a journal and virtual…
- 2003
The concept, that sleep regulatory substances (sleep factors) exist, stems from classical endocrinology and is supported by positive transfer experiments in which tissue fluids obtained from sleepy… (More)
- James M. Krueger, Jeannie A Majde
- Critical reviews in immunology
- 1994
Excessive sleepiness and fever are constitutional symptoms associated with systemic infection. Although fevers have been investigated for many years, sleep responses to infectious challenge have only… (More)
- Levente Kapás, Leon L. Hong, +4 authors James M. Krueger
- The American journal of physiology
- 1992
Exogenously administered tumor necrosis factor-alpha (TNF-alpha) elicits several symptoms of generalized infections such as fever, increased sleep, and anorexia. The aim of the present work was to… (More)
- Tetsuya Kushikata, Jianguo Fang, James M. Krueger
- The American journal of physiology
- 1999
Various growth factors are involved in sleep regulation. Brain-derived neurotrophic factor (BDNF) belongs to the neurotrophin family; it and its receptors are found in normal brain. Furthermore,… (More)
- James M. Krueger, Linda A. Toth
- Annals of the New York Academy of Sciences
- 1994
- James M. Krueger, Ferenc Obál, Jidong Fang
- Sleep medicine reviews
- 1999
We propose that sleep begins within small groups of highly interconnected neurons and is characterized by altered input --> output (i-->0) relationships for any specific neuronal group. Further,… (More)