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- J M Robins, M A Hernán, B Brumback
- Epidemiology
- 2000

In observational studies with exposures or treatments that vary over time, standard approaches for adjustment of confounding are biased when there exist time-dependent confounders that are also affected by previous treatment. This paper introduces marginal structural models, a new class of causal models that allow for improved adjustment of confounding in… (More)

- Keisuke Hirano, Guido W. Imbens, +4 authors Donald Rubin
- 2002

We are interested in estimating the average effect of a binary treatment on a scalar outcome. If assignment to the treatment is exogenous or unconfounded, that is, independent of the potential outcomes given covariates, biases associated with simple treatment-control average comparisons can be removed by adjusting for differences in the covariates.… (More)

- J M Robins, S Greenland
- Epidemiology
- 1992

We consider the problem of separating the direct effects of an exposure from effects relayed through an intermediate variable (indirect effects). We show that adjustment for the intermediate variable, which is the most common method of estimating direct effects, can be biased. We also show that even in a randomized crossover trial of exposure, direct and… (More)

- James M. Robins
- 1999

has developed a set of causal or counterfactual models, the structural nested models (SNMs). This paper describes an alternative new class of causal models-the (non-nested) marginal structural models (MSMs). We will then describe a class of semiparametric estimators for the parameters of these new models under a sequential randomization (i.e.,… (More)

- Christina E Mills, James M Robins, Marc Lipsitch
- Nature
- 2004

The 1918 influenza pandemic killed 20-40 million people worldwide, and is seen as a worst-case scenario for pandemic planning. Like other pandemic influenza strains, the 1918 A/H1N1 strain spread extremely rapidly. A measure of transmissibility and of the stringency of control measures required to stop an epidemic is the reproductive number, which is the… (More)

- S Greenland, J Pearl, J M Robins
- Epidemiology
- 1999

Causal diagrams have a long history of informal use and, more recently, have undergone formal development for applications in expert systems and robotics. We provide an introduction to these developments and their use in epidemiologic research. Causal diagrams can provide a starting point for identifying variables that must be measured and controlled to… (More)

- M A Hernán, B Brumback, J M Robins
- Epidemiology
- 2000

Standard methods for survival analysis, such as the time-dependent Cox model, may produce biased effect estimates when there exist time-dependent confounders that are themselves affected by previous treatment or exposure. Marginal structural models are a new class of causal models the parameters of which are estimated through… (More)

- Heejung Bang, James M Robins
- Biometrics
- 2005

The goal of this article is to construct doubly robust (DR) estimators in ignorable missing data and causal inference models. In a missing data model, an estimator is DR if it remains consistent when either (but not necessarily both) a model for the missingness mechanism or a model for the distribution of the complete data is correctly specified. Because… (More)

- James M. Robins
- Synthese
- 1999

- James M. Robins
- 2004

I describe two new methods for estimating the optimal treatment regime (equivalently, protocol, plan or strategy) from very high dime-sional observational and experimental data: (i) g-estimation of an optimal double-regime structural nested mean model (drSNMM) and (ii) g-estimation of a standard single regime SNMM combined with sequential… (More)