James M. Parkhurst

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Polarographical Measurement of Local Cerebral Blood Flow in the Conscious and Anesthetized Primate • This study was undertaken to evaluate the brain hemodynamics of the primate {Macaca mu-latta) in the conscious and anesthetized state. A polarographical circuit was utilized for repetitive measurements of local and average total cerebral blood flow in the(More)
Optical measurements are increasingly used in radiotherapy. In this paper we present, in detail, the design and implementation of a multi-channel optical system optimized for fast, high spatial resolution, dynamic body surface measurement in guided therapy. We include all algorithmic modifications and calibration procedures required to create a robust,(More)
An evaluation of the suitability of eight existing phase unwrapping algorithms to be used in a real-time optical body surface sensor based on Fourier fringe profilometry is presented. The algorithms are assessed on both the robustness of the results they give and their speed of execution. The algorithms are evaluated using four sets of real human body(More)
Patient motion is an important factor affecting the quality of external beam radiotherapy in breast patients. We analyse the motion of a dense set of surface points on breast patients throughout their treatment schedule to assess the magnitude and stability of motion, in particular, with respect to breast volume. We use an optical sensor to measure the(More)
OBJECTIVE To examine the in vitro and in vivo attributes of aspartame and to determine its efficacy for treating sickle cell anemia. RATIONALE Aspartame (l-aspartyl-l-phenylalanine methyl ester) binds with 2 human Bence Jones proteins. The proteins (Mcg and Sea) showed phenylalanine penetrating into hydrophobic binding sites. This aspartame property(More)
PURPOSE We present the results of a clinical feasibility study, performed in 10 healthy volunteers undergoing a simulated treatment over 3 sessions, to investigate the use of a wide-field visual feedback technique intended to help patients control their pose while reducing motion during radiation therapy treatment. METHODS AND MATERIALS An optical surface(More)
With the introduction of intensive new treatments such as hypo-fractionation and proton beam therapy, localization of the tumor target volume and tracking of points across the skin entrance surface have become critically important. Optical metrology has been used to monitor the patient's bulk position and motion throughout treatment. However systems have(More)