James M Otton

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The aim of this article is to describe a novel hardware perfusion phantom that simulates myocardial first-pass perfusion allowing comparisons between different MR techniques and validation of the results against a true gold standard. MR perfusion images were acquired at different myocardial perfusion rates and variable doses of gadolinium and cardiac(More)
BACKGROUND T1 mapping is a robust and highly reproducible application to quantify myocardial relaxation of longitudinal magnetisation. Available T1 mapping methods are presently site and vendor specific, with variable accuracy and precision of T1 values between the systems and sequences. We assessed the transferability of a T1 mapping method and determined(More)
BACKGROUND Aggressive dose reduction strategies for cardiac CT require the prospective selection of limited cardiac phases. At lower heart rates, the period of mid-diastole is typically selected for image acquisition. We aimed to identify the effect of heart rate on the optimal CT acquisition phase within the period of mid-diastole. METHODS We utilized(More)
The excellent paper by Arbab-Zadeh et al. (1) highlights the issues surrounding imaging coronary artery disease in the presence of a high calcium score; however, we are concerned that the outcome, at least in part, may result from statistical artifact. First, the negative predictive value of cardiac computed tomog-raphy in the setting of a calcium score(More)
BACKGROUND Direct comparison of CT and magnetic resonance (MR) perfusion techniques has been limited and in vivo assessment is affected by physiological variability, timing of image acquisition, and parameter selection. OBJECTIVE We precisely compared high-resolution k-t SENSE MR cardiac perfusion at 3 T with single-phase CT perfusion (CTP) under(More)
We demonstrate the feasibility of 3D myocardial perfu-sion CMR at 3 Tesla against single photon emission computer tomography for the detection and estimate of ischaemic burden and show good agreement between the techniques. This novel technique shows promising use of this method in a small cohort of patients to estimate ischaemic burden for purpose of risk(More)
The diel pattern of susceptibility to DDT of houseflies, reared under LD 14 : 10, was shown to be affected by 10 Krads of gamma radiation administered at the pupal stage. An additional peak in susceptibility of the flies to DDT corresponded to the time of irradiation of the pupae. Irradiated flies had higher general LD50 values than untreated flies. Flies(More)
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