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Product Development System (TPDS). Morgan and Liker call it Lean Product Development System, but it is really Toyota's, not American lean. It is the result of lengthy research at the University of Michigan headed by the late Alan Ward, to whom the authors give great credit. All the examples compare vehicle development between Toyota and North American car(More)
Angiotensin II, injected into the dorsal neostriatum of rats 5 minutes after they had learned a passive avoidance task, disrupted the retention of the task 24 hours later. Identical neostriatal injections given 22 hours after learning (2 hours before retention) were without effect on retention performance. Ventral neostriatum or posterior thalamus were(More)
The localisation of NK(3) tachykinin receptors in guinea-pig ileum was studied using the fluorescently labelled agonists, Cy3. 5-neurokinin A and Cy3.5-kassinin. Binding to nerve cell bodies in the myenteric and submucosal plexuses was visualised using confocal microscopy. Binding to NK(1) receptors was blocked by the NK(1) receptor antagonist, CP-99994.(More)
AIMS To evaluate the use of tissue microarray (TMA) technology as a validation tool for HER2 testing by both immunocytochemistry (ICC) and fluorescence in situ hybridisation (FISH) in the diagnostic setting. METHODS TMA constructs from 57 cases of breast cancer were evaluated for HER2 (by ICC and FISH) by two centres. The results were compared. RESULTS(More)
AIM To assess the effectiveness of clinical audit in improving standards in histopathological reporting of mastectomy specimens. METHODS Reports on mastectomy specimens containing tumour issued by non-specialist histopathologists in 1990, 1992, 1994, and 1996 were scored for their information content. There were 10 reports evaluated from each year. Before(More)
In cultured human myometrial smooth muscle cells, removal of external Na+ activates repetitive increases in intracellular Ca2+ ([Ca2+]i). The Ca2+ transients persist in isotonic K+ solutions which suggests that the activity does not arise from regenerative changes in membrane potential. In nominally Ca(2+)-free solution, the activity disappears after a few(More)
Two isomeric 6-endo- and 6-exo-(3',4'-dihydroxyphenyl) derivatives (1 and 2) of 2-azabicyclo[2.2.2]octane were synthesized as semirigid analogues of dopamine (DA) to help evaluate the preferred conformation of dopamine at the uptake site of the presynaptic nerve terminal and at the DA receptor. Against the uptake of 0.1 microM [3H]DA by a synaptosomal(More)
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