James M Lamb

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Respiration-induced organ motion is one of the major uncertainties in lung cancer radiotherapy and is crucial to be able to accurately model the lung motion. Most work so far has focused on the study of the motion of a single point (usually the tumor center of mass), and much less work has been done to model the motion of the entire lung. Inspired by the(More)
Since massive hemorrhage from the traumatized liver is usually caused by disruption of the deeply situated hepatic veins, repair or resection is seldom practical. Instead, after appropriate debridement has been accomplished, such venous bleeding can rapidly and effectively be controlled by packing autogenous omentum, based on its respective gastroepiploic(More)
Four-dimensional (4D) dose calculations for lung cancer radiotherapy have been technically feasible for a number of years but have not become standard clinical practice. The purpose of this study was to determine if clinically significant differences in tumor control probability (TCP) exist between 3D and 4D dose calculations so as to inform the decision(More)
PURPOSE To report intraoperative ultrasonography-guided positioning of iodine 125 (I(125)) plaques for brachytherapy of choroidal melanoma as a quality improvement measure. DESIGN Retrospective, single-center, consecutive case-cohort study. PARTICIPANTS One hundred fifty consecutive patients with choroidal melanoma. METHODS Patients with choroidal(More)
PURPOSE To demonstrate the preliminary feasibility of a longitudinal diffusion magnetic resonance imaging (MRI) strategy for assessing patient response to radiotherapy at 0.35 T using an MRI-guided radiotherapy system (ViewRay). METHODS Six patients (three head and neck cancer, three sarcoma) who underwent fractionated radiotherapy were enrolled in this(More)
BACKGROUND AND PURPOSE To quantify the benefit of motion-specific internal target volumes for FDG-avid mediastinal and hilar lymph nodes generated using 4D-PET, vs. conventional internal target volumes generated using non-respiratory gated PET and 4D-CT scans. MATERIALS AND METHODS Five patients with FDG-avid tumors metastatic to 11 hilar or mediastinal(More)
PURPOSE The purpose of this study was to develop a methodology to quantitatively measure the thorax-to-abdomen breathing ratio from a 4DCT dataset for breathing motion modeling and breathing motion studies. METHODS The thorax-to-abdomen breathing ratio was quantified by measuring the rate of cross-sectional volume increase throughout the thorax and(More)
PURPOSE Magnetic resonance image (MRI) guided radiotherapy enables gating directly on the target position. We present an evaluation of an MRI-guided radiotherapy system's gating performance using an MRI-compatible respiratory motion phantom and radiochromic film. Our evaluation is geared toward validation of our institution's clinical gating protocol which(More)
PURPOSE To determine whether image guidance with rigid registration (RR) to intraprostatic markers (IPMs) yields acceptable coverage of the pelvic lymph nodes in the context of a stereotactic body radiation therapy (SBRT) regimen. METHODS AND MATERIALS Four to seven kilovoltage cone-beam CTs (CBCTs) from 12 patients with high-risk prostate cancer were(More)
PURPOSE To develop a technique that assesses the accuracy of the breathing phase-specific volume image generation process by patient-specific breathing motion model using the original free-breathing computed tomographic (CT) scans as ground truths. METHODS Sixteen lung cancer patients underwent a previously published protocol in which 25 free-breathing(More)