James M. DeLeo

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Computed transverse axial tomography (CT) was employed to examine brain morphometrics in 30 healthy men, aged 21 to 81 years. Seven consecutive CT slices 30 to 80 mm above the inferior orbitomeatal line were analyzed. CT numbers in gray and white matter regions were not correlated significantly with age (p greater than 0.05), nor were right/left ratios for(More)
A computer-assisted method was employed to estimate the amounts of cerebrospinal fluid (CSF), white matter, and gray matter in individual computerized tomography (CT) scans of brains. By means of an image processing procedure (DMORPH), the means +/- SD CT numbers of "pure" CSF, white matter, and gray matter were determined in each scan and stored. A CATSEG(More)
The clinical accuracy of diagnostic tests commonly is assessed by ROC analysis. ROC plots, however, do not directly incorporate the effect of prevalence or the value of the possible test outcomes on test performance, which are two important factors in the practical utility of a diagnostic test. We describe a new graphical method, referred to as a(More)
Developing intelligent tools to extract information from data collections has long been of critical importance in fields such as knowledge discovery, information retrieval, pattern recognition, and databases. With the advent of electronic medical records and medical data repositories there is new potential to apply these techniques to the analysis of(More)
We developed a methodology for constructing scoring systems to support bivalent decision making in clinical medicine. Such systems could be of great benefit in forced-choice decision-making situations as well as in triaging, screening, and diagnostic applications. Our methodology combines medical judgment with explicit computer-derived information to(More)
Artificial neural networks (ANNs), computer paradigms that can learn, excel in pattern recognition tasks such as disease diagnosis. Artificial neural networks operate in two different learning modes: supervised, in which a known diagnostic outcome is presented to the ANN, and unsupervised, in which the diagnostic outcome is not presented. A supervised(More)
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