James Love

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Electron microscopy of two-dimensional (2D) crystals has demonstrated potential for structure determination of membrane proteins. Technical limitations in large-scale crystallization screens have, however, prevented a major breakthrough in the routine application of this technology. Dialysis is generally used for detergent removal and reconstitution of the(More)
T he AIDS crisis has brought to public notice what has always been generally true—that the existing business model for drug development leads to high prices and unequal access. There is now widespread dissatisfaction with drug prices in both the developed (Families USA 2003) and developing world (Correa 2000). Governments and health insurers are fi nding(More)
Electron crystallography relies on electron cryomicroscopy of two-dimensional (2D) crystals and is particularly well suited for studying the structure of membrane proteins in their native lipid bilayer environment. To obtain 2D crystals from purified membrane proteins, the detergent in a protein-lipid-detergent ternary mixture must be removed, generally by(More)
This article argues that prizes can help stimulate medical innovation, control costs and ensure greater access to new medicines and vaccines. The authors explore four increasingly ambitious prize options to reward medical innovation, each addressing flaws in the current patent system. The first option promotes innovation through a large prize fund linked to(More)
Transatlantic Consumer Dialogue, and all those others who worked hard to provide us with up-to-date and hard-to-obtain information about this once-secret treaty. ―One feels that you're almost in a bit of a twilight zone. I mean, we're talking about a copyright treaty. And it's being treated as akin to nuclear secrets.‖ — Michael Geist 1 ―Drafting treaties(More)
The Joint Special Operations University (JSOU) provides its publications to contribute toward expanding the body of knowledge about joint special operations. JSOU publications advance the insights and recommendations of national security professionals and the Special Operations Forces (SOF) students and leaders for consideration by the SOF community and(More)
In the future, we may be faced with the need to provide treatment for an emergent biological threat against which existing vaccines and drugs have limited efficacy or availability. To prepare for this eventuality, our objective was to use a metabolic network-based approach to rapidly identify potential drug targets and prospectively screen and validate(More)
Traditionally, countries have allowed second and later drug applicants (generic manufacturers) to register their product with regulatory authorities during the patent term for different purposes: a) to early register so that the generic drugs are prepared to promptly enter the market when the originator's patent expires 3 ; b) to register when the drug has(More)
Previous research on the biomechanics of tool use has focused heavily on traits correlated with locomotion, tool manufacturing, and habitual tool use. Features like the breadth of the metacarpals, relative length of the thumb, styloid process of the third metacarpal, and the breadth of the apical tufts are skeletal features associated with the use and(More)