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This study assesses whether participating in games based learning can improve mathematical skills in students with intellectual disabilities (ID), a functional skill that promotes greater inclusion in society, health and well being. Sixteen key stage 2 to 5 students with ID participated in the study. A matched pairs design was used, with 8 students playing(More)
Somatic mutations in spliceosome genes are detectable in ∼50% of patients with myelodysplastic syndromes (MDS). We hypothesize that cells harbouring spliceosome gene mutations have increased sensitivity to pharmacological perturbation of the spliceosome. We focus on mutant U2AF1 and utilize sudemycin compounds that modulate pre-mRNA splicing. We find that(More)
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