James Lewis Wardell

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This paper describes the antiviral evaluation of new N-amino-1,2,3-triazole derivatives, 1-(substituted-phenylamino)-5-methyl-1H-[1,2,3]-triazole-4-carboxylic acid ethyl esters, 3 and 1-(4-substituted-phenylamino)-5-methyl-1H-[1,2,3]-triazole-4-carboxylic acid hydrazides, 4, on Cantagalo virus replication.(More)
The copper(II) complexes [Cu(H2Am4DH)Cl2] (1), [Cu(H2Am4Me)Cl2] (2), [Cu(H2Am4Et)Cl2] (3) and [Cu(2Am4Ph)Cl] (4) with 2-pyridineformamide thiosemicarbazone (H2Am4DH) and its N(4)-methyl (H2Am4Me), N(4)-ethyl (H2Am4Et) and N(4)-phenyl (H2Am4Ph) derivatives were studied by means of infrared and EPR spectral techniques. The crystal structure of 4 was(More)
A series of N-acylhydrazonyl-thienyl derivatives (compounds 2 and 3), mainly of the type 2-(aryl-CH=N-NHCOCH2 )-thiene (2: aryl = substituted-phenyl; 3: aryl = heteroaryl) were evaluated against Mycobacterium tuberculosis. Particularly active compound was 3 (heteroaryl = 5-nitrothien-2-yl or 5-nitrofuran-2-yl) with MIC values of 8.5 and 9.0 μM,(More)
In each of the asymmetrically substituted disulfides 2-nitro-4'-methyldiphenyl disulfide, C(13)H(11)NO(2)S(2) (1), 2-nitro-4'-chlorodiphenyl disulfide, C(12)H(8)ClNO(2)S(2) (2), 2, 4-dinitro-4'-methyldiphenyl disulfide, C(13)H(10)N(2)O(4)S(2) (3), and 2,4-dinitrophenyl-2'-methoxycarbonylmethyl disulfide, C(9)H(8)N(2)O(6)S(2) (4), and in both of the(More)
Anilinium 2-carboxy-4-nitrobenzoate, C6H8N+.C8H4NO6-, (I), 4-chloroanilinium 2-carboxy-4-nitrobenzoate, C6H7ClN+.C8H4NO6-, (II), 4-bromoanilinium 2-carboxy-4-nitrobenzoate, C6H7BrN+.C8H4NO6-, (III), and 4-iodoanilinium 2-carboxy-4-nitrobenzoate, C6H7IN+.C8H4NO6-, (IV), are approximately isostructural. In each compound, the ions are linked into complex(More)
The structure of the triclinic polymorph of acetone 2,4-dinitrophenylhydrazone, C(9)H(10)N(4)O(4), has been redetermined from diffraction data collected at 120 (2) K; the molecules are linked by C-H...O hydrogen bonds into centrosymmetric R(2)(2)(10) dimers which are themselves linked into a chain by an aromatic pi-pi stacking interaction. In the monoclinic(More)
1-(2-Chloronicotinoyl)-2-(2-nitrophenyl)hydrazine, C12H9ClN4O3, crystallizes in three polymorphic forms, two monoclinic forms in space groups Cc (Ia) and P2(1) (Ib), and an orthorhombic form in space group Pbcn (Ic). In the Cc polymorph (Ia) the molecules are linked into sheets by combinations of one N-H...O and two C-H...O hydrogen bonds, while in the(More)
Seven members of the methyl-6-O-(n-acyl)-α-D-glucopyranosides have been synthesised and their transitional properties determined. The undecanoyl and octadecanoyl members do not exhibit liquid crystallinity while the members having chain lengths between dodecanoyl and hexadecanoyl exhibit a monotropic smectic A phase. Variable temperature infrared(More)
In this work, we report the synthesis and the antitubercular evaluation of 16 new mefloquine derivatives, formed from reactions between mefloquine and benzaldehydes, with the activity expressed as the minimum inhibitory concentration (MIC) in μM. The compounds were non-cytotoxic and exhibited an important activity (12.6 μM). The appreciable activity of(More)
A series of 23 racemic mefloquine-oxazolidine derivatives, 4-[3-(aryl)hexahydro[1,3]oxazolo[3,4-a]pyridin-1-yl]-2,8-bis(trifluoromethyl)quinolines, derived from (R*, S*)-(±)-mefloquine and arenealdehydes, have been evaluated for their activity against four cancer cell lines (HCT-8, OVCAR-8, HL-60, and SF-295). Good cytotoxicities have been determined with(More)