James L. Sebastian

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PURPOSE We assessed the feasibility of a large randomized trial intended to determine whether low-dose heparin prophylaxis given throughout hospitalization reduces mortality and morbidity in general medical patients. SUBJECTS AND METHODS Hospitalized general medical patients aged more than 60 years at 5 Department of Veterans Affairs (VA) medical centers(More)
OBJECTIVES To determine the efficacy of a three-fold reduced dose (RD, 27 mg) of intravesical bacille Calmette-Guérin (BCG) against the standard dose (81 mg) in patients with superficial bladder cancer, assessing recurrence, progression and differences in toxicity. PATIENTS AND METHODS Five hundred patients with superficial bladder cancer (Ta, T1, Tis)(More)
Individual HLA homozygous parthenogenetic human stem cell (hpSC-Hhom) lines have the potential for cell-based therapy in a significant number of individuals, provided the HLA haplotype is prevalent. We report the successful derivation of four stable hpSC-Hhom lines from both HLA homozygous and HLA heterozygous donors. Of these, the hpSC-Hhom-4 line carries(More)
Purpose – The purpose of this article is to propose one possible framework for conceptualizing the preparation of leaders for social justice. To this end, three central questions guided this conceptualization: “What are the common themes in the literature and research on preparing leaders for social justice?”; “How can this framework serve as a guide for(More)
BACKGROUND The mini-clinical evaluation exercise (mini-CEX) has been used to assess clinical skills of 3rd-year medical schools. However a PDA-based mini-CEX has not been developed or evaluated before. Our objective was to determine the feasibility, implementation, and user satisfaction with a PDA-based mini-CEX. DESCRIPTION Third-year medical students at(More)
Urine contains inhibitors of calcium oxalate (CaOx) crystal growth. One such inhibitor is nephrocalcin (NC), a glycoprotein which is made in the kidney and contains several residues of gamma-carboxyglutamic acid (Gla) per molecule. The presence of Gla may be important to its ability to inhibit crystal growth. Several studies suggest that vitamin K-dependent(More)
A case of crossed ectopia with a solitary kidney in a 73-year-old man is presented. The fact that the kidney is normally situated and vascularized, and the presence of a second blind homolateral ureter leads us to conclude that this is a case of crossed ureteral ectopia in a solitary kidney. The embryogenesis of the malformation is discussed.
To determine the frequency of ACE inhibitor cough in an outpatient medical clinic population, a cross-sectional epidemiologic survey using mailed questionnaires was done. Patients were randomly selected from a computerized hospital pharmacy data base. The overall prevalence of cough was 19 percent in the ACE inhibitor groups compared with 9 percent in the(More)