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For a fixed positive integer k, a k-tuple total dominating set of a graph G is a subset D ⊆ V (G) such that every vertex of G is adjacent to at least k vertices in D. The k-tuple total domination problem is to determine a minimum k-tuple total dominating set of G. This paper studies k-tuple total domination from an algorithmic point of view. In particular,… (More)

Colchicine is an active alkaloid that is commonly used for treatment of multiple diseases including gout, primary biliary cirrhosis and familial Mediterranean fever. Less commonly, it has been implicated in several fatal overdoses. Deaths from colchicine overdoses are usually due to multi-organ failure, whether directly from colchicine toxicity or due to… (More)