James K. Grant

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Advanced melanoma has a poor prognosis and chemotherapy provides little benefit for most patients. This may be related to heterogeneity of chemosensitivity as well as frequent constitutive resistance to individual cytotoxic drugs. We have therefore examined the heterogeneity of chemosensitivity in metastatic cutaneous melanoma specimens using an ex vivo(More)
17B-Hydroxy-5a-androstan-3-one (dihydrotestosterone) may be the active androgen required for maintenance of many androgen-dependent tissues (King & Mainwaring, 1974). In the human prostate gland, testosterone is converted into dihydrotestosterone by aNADPH-dependent A4-3-oxosteroid 5a-oxidoreductase (5a-reductase) (Ofner et al., 1970). This enzyme has been(More)
Using arginase and hydroxyproline as biochemical markers, the yields and homogeneity of separated epithelial and stromal tissues from surgically removed benign hyperplastic prostate glands have been assessed. On the basis of these markers, about 30% of epithelial and 95% of stromal tissues were recovered. Dehydroepiandrosterone sulphate sulphatase activity(More)