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Paraquat, a quaternary ammonium bipyridyl herbicide, produces degenerative lesions in the lung after systemic administration to man and animals. The pulmonary toxicity of paraquat resembles in several ways the toxicity of several other lung toxins, including oxygen, nitrofurantoin and bleomycin. Although a definitive mechanism of toxicity of paraquat has(More)
In this paper, we introduce Block Jam, a Tangible User Interface that controls a dynamic polyrhythmic sequencer using 26 physical artifacts. These physical artifacts, that we call blocks, are a new type of input device for manipulating an interactive music system. The blocks' functional and topological statuses are tightly coupled to an ad hoc sequencer,(More)
The purpose of this study was to investigate the hypothesis that paraquat pulmonary toxicity results from cyclic reduction-oxidation of paraquat with sequential generation of superoxide radicals and singlet oxygen and initiation of lipid peroxidation. In vitro mouse lung microsomes catalyzed an NADPH-dependent, single-electron reduction of paraquat.(More)
The toxicity, exposure, and risk from chlorpyrifos are briefly discussed in juxtaposition with two recent articles in Environmental Health Perspectives concerning potential exposures to children. In studies conducted according to EPA guidelines, chlorpyrifos has been shown not to be mutagenic, carcinogenic, or teratogenic, nor does it adversely affect(More)
The effects of exposure to four environmental rearing conditions on subsequent voluntary ethanol intake were examined. Male weanling rats were were reared in either an enriched environment or individually for 90 days. After the 90-day environmental exposure period, the initial groups (Enriched and Isolated) were randomly subdivided into four groups(More)
Signal-derived measures can provide effective ways towards quantifying human behavior. Verbal Response Latencies (VRLs) of children with Autism Spectrum Disorders (ASD) during conversational interactions are able to convey valuable information about their cognitive and social skills. Motivated by the inherent gap between the external behavior and inner(More)
Propionic acid, an enteric bacterial fermentation product, has received recent attention in regards to satiety and obesity in humans. The possibility that propionic acid might produce internal aversive cues was investigated in two experiments using conditioned taste avoidance and place avoidance procedures to index the potential aversive nature of systemic(More)
Speech and spoken language cues offer a valuable means to measure and model human behavior. Computational models of speech behavior have the potential to support health care through assistive technologies, informed intervention, and efficient long-term monitoring. The Interspeech 2013 Autism Sub-Challenge addresses two developmental disorders that manifest(More)
Behavioral coding focuses on deriving higher-level behavioral annotations using observational data of human interactions. Automatically identifying salient events in the observed signal data could lead to a deeper understanding of how specific events in an interaction correspond to the perceived high-level behaviors of the subjects. In this paper, we(More)