BACKGROUND Vasodilator-stimulated phosphoprotein (VASP) mediates focal adhesion, actin filament binding and polymerization in a variety of cells, thereby inhibiting cell movement. Phosphorylation of VASP via cAMP and cGMP dependent protein kinases releases this "brake" on cell motility. Thus, phosphorylation of VASP may be necessary for epithelial cell… (More)
BACKGROUND The role of fixed airflow obstruction (FAO) in asthma is unclear. OBJECTIVE To assess the relationship between FAO and clinical features of asthma and the effect of FAO on treatment response. METHODS Post hoc descriptive analysis of data stratified by FAO category (screening post-albuterol FEV1/FVC <lower limit of normal [LLN] [FAO+] or ≥LLN… (More)
BACKGROUND Previous studies have shown disparities between Black and Hispanic patients compared with other populations in response to asthma medications. OBJECTIVE The aim of this analysis was to assess the effect of budesonide/formoterol pressurized metered-dose inhaler (BUD/FM pMDI) and BUD on predefined criteria for asthma worsening, an asthma control… (More)
The effect of budesonide/formoterol pressurized metered-dose inhaler on predefined criteria for worsening asthma in four different patient populations with asthma.